Azzolini Elena, Mollura Maximiliano, Pozzi Chiara, Ubaldi Leonardo, Mantovani Alberto, Selmi Carlo, Barbieri Riccardo, Rescigno Maria
IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, Italy.
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, MI, Italy.
Vaccines (Basel). 2023 Feb 22;11(3):505. doi: 10.3390/vaccines11030505.
An important issue that is often neglected is the difference between male and female genders in response to medical treatments. In the context of COVID-19 vaccine administration, despite identical protocol strategies, it has been observed that females often suffer more adverse consequences than males. Here, we analyzed the adverse events (AEs) of the Comirnaty vaccine in a population of 2385 healthcare workers as a function of age, sex, COVID-19 history and BMI. Using logistic regression analysis, we showed that these variables may contribute to the development of AEs, particularly in young subjects, females and individuals with a BMI below 25 kg/m. Moreover, partial dependence plots indicate a 50% probability of developing a mild AE for a long period of time (≥7 days) or a severe AE of any duration in women below 40 years old and with a BMI < 20 kg/m. As this effect is more evident after the second dose of the vaccine, we propose to reduce the amount of vaccine for any additional booster dose in relation to age, sex and BMI. This strategy might reduce adverse events without affecting vaccine efficacy.
一个经常被忽视的重要问题是男性和女性在对医疗治疗反应方面的差异。在新冠疫苗接种的背景下，尽管采用了相同的方案策略，但据观察，女性往往比男性遭受更多的不良后果。在此，我们分析了2385名医护人员接种辉瑞疫苗后的不良事件（AE），这些不良事件是年龄、性别、新冠病史和体重指数的函数。通过逻辑回归分析，我们表明这些变量可能导致不良事件的发生，特别是在年轻受试者、女性以及体重指数低于25kg/m的个体中。此外，部分依赖图表明，40岁以下且体重指数<20kg/m的女性，长时间（≥7天）出现轻度不良事件或出现任何持续时间的严重不良事件的概率为50%。由于这种效应在接种第二剂疫苗后更为明显，我们建议根据年龄、性别和体重指数减少任何额外加强剂量的疫苗量。这一策略可能会减少不良事件，而不影响疫苗效力。
