Urakawa Ryuta, Isomura Emiko Tanaka, Matsunaga Kazuhide, Kubota Kazumi
Department of Pharmacy, Osaka University Dental Hospital, 1-8 Yamada-oka, Suita 565-0871, Osaka, Japan.
Department of Clinical Pharmacy Research and Education, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita 565-0871, Osaka, Japan.
Vaccines (Basel). 2022 Aug 19;10(8):1357. doi: 10.3390/vaccines10081357.
This study compared the adverse events (AEs) of the second and third doses of BNT162b2, as well as investigated the impact of vaccine recipients' background and vaccination interval on the AEs of the third dose.
We conducted a questionnaire survey of AEs among health care workers at Osaka University Dental Hospital. Chi-square tests were performed to compare AEs to the administration of second and third vaccine doses. Logistic regression analyses were conducted to identify factors influencing the presence of AEs using age, sex, comorbidities, and the vaccination interval. Spearman's rank correlation coefficient was calculated to investigate the correlation between age, vaccination interval, and severity of each AE.
The third dose of BNT162b2 was associated with significantly more frequent or milder AEs than the second dose. Logistic regression analyses detected significant differences in six items of AEs by age, three by sex, two by comorbidities, and zero by vaccination interval. Consistently, the risk of AEs was greater among younger persons, females, and those without comorbidities. Significant negative correlations were detected between age and vaccination interval, and between age and the severity of most AEs.
Young, female, and having no comorbidities are risk factors for AEs after the third dose of BNT162b2, while vaccination interval is not.
本研究比较了BNT162b2第二剂和第三剂的不良事件（AE），并调查了疫苗接种者的背景和接种间隔对第三剂AE的影响。
我们对大阪大学牙医院的医护人员进行了AE问卷调查。进行卡方检验以比较第二剂和第三剂疫苗接种后的AE。进行逻辑回归分析以确定使用年龄、性别、合并症和接种间隔影响AE发生的因素。计算Spearman等级相关系数以研究年龄、接种间隔和每种AE严重程度之间的相关性。
BNT162b2第三剂比第二剂的AE发生频率显著更高或更轻微。逻辑回归分析发现，按年龄有6项AE存在显著差异，按性别有3项，按合并症有2项，按接种间隔则无差异。一致地，年轻人、女性和无合并症者发生AE的风险更大。在年龄与接种间隔之间，以及年龄与大多数AE的严重程度之间检测到显著的负相关。
年轻、女性和无合并症是BNT162b2第三剂后发生AE的风险因素，而接种间隔则不是。
