Kim Jaejo, Lee Seung-Heon, Kim Ha-Hyun, Park Jong-Hyeon, Park Choi-Kyu
Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City 39660, Republic of Korea.
College of Veterinary Medicine & Animal Disease Intervention Center, Kyungpook National University, Daegu 41566, Republic of Korea.
Vaccines (Basel). 2023 Feb 25;11(3):551. doi: 10.3390/vaccines11030551.
Three commercial vaccines are administered in domestic livestock farms for routine vaccination to aid for foot-and-mouth disease (FMD) control in Korea. Each vaccine contains distinct combinations of inactivated serotype O and A FMD virus (FMDV) antigens: O/Manisa + O/3039 + A/Iraq formulated in a double oil emulsion (DOE), O/Primorsky + A/Zabaikalsky formulated in a DOE, and O/Campos + A/Cruzeiro + A/2001 formulated in a single oil emulsion. Despite the recommendation for a prime-boost vaccination with the same vaccine in fattening pigs, occasional cross-inoculation is inevitable for many reasons, such as lack of compliance with vaccination guidelines, erroneous application, or change in vaccine types by suppliers. Therefore, there have been concerns that a poor immune response could be induced by cross-inoculation due to a failure to boost the immune response. In the present study, it was demonstrated by virus neutralization and ELISA tests that cross-inoculation of pigs with three commercial FMD vaccines does not hamper the immune response against the primary vaccine strains and enhances broader cross-reactivity against heterologous vaccine antigens whether they were applied or not. Therefore, it could be concluded that the cross-inoculation of FMD vaccines can be used as a regimen to strategically overcome the limitation of the antigenic spectrum induced by the original regimen.
韩国的家畜养殖场使用三种商用疫苗进行常规接种，以协助控制口蹄疫（FMD）。每种疫苗都含有不同组合的O型和A型口蹄疫病毒（FMDV）灭活抗原：双油乳剂（DOE）中配制的O/Manisa + O/3039 + A/伊拉克、DOE中配制的O/滨海边疆区 + A/外贝加尔边疆区，以及单油乳剂中配制的O/坎波斯 + A/克鲁塞罗 + A/2001。尽管建议对育肥猪使用相同的疫苗进行初免-加强免疫接种，但由于多种原因，如不遵守疫苗接种指南、错误应用或供应商更换疫苗类型，偶尔的交叉接种是不可避免的。因此，人们担心交叉接种可能会因无法增强免疫反应而导致免疫反应不佳。在本研究中，通过病毒中和试验和ELISA试验证明，用三种商用口蹄疫疫苗对猪进行交叉接种不会妨碍对主要疫苗株的免疫反应，并且无论是否应用异源疫苗抗原，都能增强对其更广泛的交叉反应性。因此，可以得出结论，口蹄疫疫苗的交叉接种可以作为一种策略性方案，以克服原方案引起的抗原谱限制。
