Shin Sehee, Park So Hui, Park Jong-Hyeon, Kim Su-Mi, Lee Min Ja
Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, Korea.
Vaccines (Basel). 2022 Apr 24;10(5):677. doi: 10.3390/vaccines10050677.
Vaccine-induced active immunity in young animals may be compromised via interference caused by maternally derived antibodies (MDAs). Since the level, titer, and half-life of MDAs vary per individual, it is difficult to determine the appropriate timing of foot-and-mouth disease (FMD) vaccination in the field. In order to better understand the age-dependent characteristics of MDA in sows and piglets as well as the phenomenon of reduced vaccine-mediated active immunity due to MDAs, this study sought to determine antibody titers through structural protein (SP) O, A ELISA analyses, and virus-neutralizing (VN) antibody titers as well as their half-lives in the sera of sows and piglets derived from FMD-vaccinated mother. Furthermore, immunoglobulin (Ig) subtypes, such as IgG, IgM, and IgA, in serum were also evaluated. To understand the correlation between the inhibition of vaccine-mediated active immunity by MDA-mediated passive immunity and regulatory T (T) cells, T-related cytokine levels were explored. Our findings will help to predict the optimal timing of vaccination for overcoming MDAs and inducing a robust vaccine-mediated immune response in young individuals vaccinated against FMD. They also add to our understanding of MDA characteristics and interference, providing insight for the development of innovative strategies and novel FMD vaccine for overcoming such interference.
幼龄动物中疫苗诱导的主动免疫可能会因母源抗体（MDA）引起的干扰而受到影响。由于MDA的水平、效价和半衰期因个体而异，因此在实际中很难确定口蹄疫（FMD）疫苗接种的合适时机。为了更好地了解母猪和仔猪中MDA的年龄依赖性特征以及MDA导致疫苗介导的主动免疫降低的现象，本研究试图通过结构蛋白（SP）O、A ELISA分析以及病毒中和（VN）抗体效价来确定抗体效价，以及它们在接种FMD疫苗的母猪和仔猪血清中的半衰期。此外，还评估了血清中的免疫球蛋白（Ig）亚型，如IgG、IgM和IgA。为了了解MDA介导的被动免疫对疫苗介导的主动免疫的抑制与调节性T（T）细胞之间的相关性，还探究了T相关细胞因子水平。我们的研究结果将有助于预测克服MDA并在接种FMD疫苗的幼龄个体中诱导强大的疫苗介导免疫反应的最佳接种时机。它们还增进了我们对MDA特征和干扰的理解，为开发克服此类干扰的创新策略和新型FMD疫苗提供了见解。
