Alcantara Cheldon Ann, Glassman Ira, Nguyen Kevin H, Parthasarathy Arpitha, Venketaraman Vishwanath
Department of Basic Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Division of Biology, Pitzer College, Claremont, CA 91711, USA.
Vaccines (Basel). 2023 Mar 12;11(3):631. doi: 10.3390/vaccines11030631.
() continues to be a leading cause of mortality within developing countries. The BCG vaccine to promote immunity against is widely used in developing countries and only in specific circumstances within the United States. However, current the literature reports equivocal data on the efficacy of the BCG vaccine. Critical within their role in the innate immune response, neutrophils serve as one of the first responders to infectious pathogens such as . Neutrophils promote effective clearance of through processes such as phagocytosis and the secretion of destructive granules. During the adaptative immune response, neutrophils modulate communication with lymphocytes to promote a strong pro-inflammatory response and to mediate the containment through the production of granulomas. In this review, we aim to highlight and summarize the role of neutrophils during an infection. Furthermore, the authors emphasize the need for more studies to be conducted on effective vaccination against .
（）仍然是发展中国家主要的死亡原因。用于增强针对（）免疫力的卡介苗在发展中国家广泛使用，在美国仅在特定情况下使用。然而，目前的文献报道了关于卡介苗功效的不确定数据。在其先天免疫反应中的作用至关重要，中性粒细胞是对诸如（）等感染性病原体的首批反应者之一。中性粒细胞通过吞噬作用和分泌破坏性颗粒等过程促进（）的有效清除。在适应性免疫反应期间，中性粒细胞调节与淋巴细胞的通讯，以促进强烈的促炎反应，并通过产生肉芽肿来介导（）的遏制。在本综述中，我们旨在突出并总结中性粒细胞在（）感染期间的作用。此外，作者强调需要针对针对（）的有效疫苗接种开展更多研究。
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