Choi Ji Soo, Mital Dushyant, Ahmed Mohamed H, Raza Mohammed M
Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.
Department of HIV and Blood Borne Viruses, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.
J Family Med Prim Care. 2022 Nov;11(11):7456-7459. doi: 10.4103/jfmpc.jfmpc_985_22. Epub 2022 Dec 16.
We report a case of a 46-year-old female with HIV for the last 15 years admitted to our hospital with a history of fever. She was diagnosed with pneumonia and was treated with antibiotics and recovered well; however, she was found to be hyponatremic. She mentioned that she tested positive for coronavirus disease 2019 (COVID-19) 4 months prior to the admission, and she gradually lost weight since. Further investigation for hyponatremia showed that she had Addison's disease with isolated adrenocorticotropic hormone (ACTH) deficiency. Magnetic resonance imaging of the pituitary was normal, and all auto-immune, hormonal, and biochemical investigations were normal. COVID-19 is also associated with adrenal insufficiency, and we suggest that further research is needed to establish the link between adrenal insufficiency and COVID-19. Our case report is unique as it demonstrates isolated ACTH deficiency leading to adrenal insufficiency following COVID-19 infections.
我们报告一例46岁女性，她感染HIV已达15年，因发热病史入住我院。她被诊断为肺炎，接受抗生素治疗后恢复良好；然而，她被发现存在低钠血症。她提到在入院前4个月新冠病毒病2019（COVID-19）检测呈阳性，自那以后体重逐渐减轻。对低钠血症的进一步检查显示她患有艾迪生病，伴有孤立性促肾上腺皮质激素（ACTH）缺乏。垂体磁共振成像正常，所有自身免疫、激素和生化检查均正常。COVID-19也与肾上腺功能不全有关，我们建议需要进一步研究以确定肾上腺功能不全与COVID-19之间的联系。我们的病例报告很独特，因为它显示了COVID-19感染后孤立性ACTH缺乏导致肾上腺功能不全。
