Downie A E, Oyesola O, Barre R S, Caudron Q, Chen Y-H, Dennis E J, Garnier R, Kiwanuka K, Menezes A, Navarrete D J, Mondragón-Palomino O, Saunders J B, Tokita C K, Zaldana K, Cadwell K, Loke P, Graham A L
Department of Ecology and Evolutionary Biology, Princeton University; Princeton, NJ 08544, USA.
Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA.
bioRxiv. 2023 Mar 16:2023.03.15.532825. doi: 10.1101/2023.03.15.532825.
Environmental influences on immune phenotypes are well-documented, but our understanding of which elements of the environment affect immune systems, and how, remains vague. Behaviors, including socializing with others, are central to an individual's interaction with its environment. We tracked behavior of rewilded laboratory mice of three inbred strains in outdoor enclosures and examined contributions of behavior, including social associations, to immune phenotypes. We found that the more associated two individuals were, the more similar their immune phenotypes were. Social association was particularly predictive of similar memory T and B cell profiles and was more influential than sibling relationships or worm infection status. These results highlight the importance of social networks for immune phenotype and reveal important immunological correlates of social life.
环境对免疫表型的影响已有充分记录，但我们对环境中的哪些因素会影响免疫系统以及如何影响仍不清楚。行为，包括与他人社交，是个体与环境相互作用的核心。我们追踪了三种近交系野生化实验小鼠在户外围栏中的行为，并研究了包括社会交往在内的行为对免疫表型的影响。我们发现，两个个体之间的关联越多，它们的免疫表型就越相似。社会交往尤其能预测相似的记忆T细胞和B细胞谱，并且比亲缘关系或蠕虫感染状态更具影响力。这些结果突出了社会网络对免疫表型的重要性，并揭示了社会生活的重要免疫相关因素。
