Daniel F B, Schenck K M, Mattox J K, Lin E L, Haas D L, Pereira M A
Fundam Appl Toxicol. 1986 Apr;6(3):447-53. doi: 10.1016/0272-0590(86)90218-6.
Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl)pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, we have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard.
对氯化和溴化卤代乙腈（HAN）这两种已知在氯消毒过程中形成的饮用水污染物的遗传毒性活性进行了研究。HAN在培养的人淋巴细胞（CCRF - CEM）中产生DNA链断裂，与亲核捕获剂4 - （对硝基苄基）吡啶结合，并在无细胞反应体系中与聚腺苷酸形成共价键。因此，我们已证明这些化学物质具有遗传毒性，这表明它们具有致癌活性和对人类健康造成危害的可能性。
