La Rocca Gaetano, Ferro Francesco, Baldini Chiara, Libra Alessandro, Sambataro Domenico, Colaci Michele, Malatino Lorenzo, Palmucci Stefano, Vancheri Carlo, Sambataro Gianluca
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Regional Referral Centre for Rare Lung Disease, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", University of Catania, Catania, Italy.
Front Med (Lausanne). 2023 Mar 13;10:1158768. doi: 10.3389/fmed.2023.1158768. eCollection 2023.
In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these molecules transduce their signal through a receptor coupled with Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT). In this review, we discuss the role of the JAK/STAT pathway in IIM, evaluate a possible therapeutic role for JAK inhibitors in this group of diseases, focusing on those with the strongest IFN signature (dermatomyositis and antisynthetase syndrome).
近几十年来，多项证据使人们更加关注先天性免疫这一主题，尤其是干扰素（IFN）和白细胞介素6在特发性炎性肌病（IIM）发病机制中的作用。这两种分子都通过与Janus激酶（JAK）/信号转导子和转录激活子（STAT）偶联的受体来转导其信号。在本综述中，我们讨论了JAK/STAT通路在IIM中的作用，评估了JAK抑制剂在这类疾病中的潜在治疗作用，重点关注那些具有最强IFN特征的疾病（皮肌炎和抗合成酶综合征）。
