Department of Psychology, Drexel University, Philadelphia, PA, USA.
The WELL Center, Drexel University, Philadelphia, PA, USA.
Eat Weight Disord. 2023 Mar 30;28(1):34. doi: 10.1007/s40519-023-01558-z.
Difficulty reappraising drives to consume palatable foods may promote poorer inhibition and binge eating (BE) in adults with obesity, but neural underpinnings of food-related reappraisal are underexamined.
To examine neural correlates of food-related reappraisal, adults with obesity with and without BE wore a portable neuroimaging tool, functional near-infrared spectroscopy (fNIRS). fNIRS measured activity in the prefrontal cortex while participants watched videos of food and attempt to "resist" the food stimuli (i.e., "consider the negative consequences of eating the food").
Participants (N = 32, 62.5% female; BMI 38.6 [Formula: see text] 7.1; 43.5 [Formula: see text] 13.4 y) had a BMI > 30 kg/m. Eighteen adults (67.0% female; BMI 38.2 [Formula: see text] 7.6) reported BE (≥ 12 BE-episodes in preceding 3 months). The control group comprised 14 adults who denied BE (64.0% female; BMI 39.2 [Formula: see text] 6.6). Among the entire sample, mixed models showed significant, small hyperactivation during crave and resist compared to watch (relax) condition bilaterally in the medial superior frontal gyrus, dorsolateral areas, and middle frontal gyrus (optodes 5, 7, 9, 10, 11, and 12) in the total sample. No statistically significant differences in neural activation were observed between the BE and control group. Moreover, there were no significant group by condition interactions on neural activation.
Among adults with obesity, BE status was not linked to differential activation in inhibitory prefrontal cortex areas during a food-related reappraisal task. Future research is needed with larger samples, adults without obesity, and inhibition paradigms with both behavioral and cognitive components.
Level III: Evidence obtained from well-designed cohort or case-control analytic studies.
重新评估进食美味食物的难度可能会导致肥胖成年人的抑制能力下降和暴食（BE），但与食物相关的再评价的神经基础研究还不够充分。
为了研究与食物相关的再评价的神经相关性，肥胖且有或没有 BE 的成年人佩戴了便携式神经影像学工具，功能性近红外光谱（fNIRS）。当参与者观看食物视频并试图“抵制”食物刺激（即“考虑吃食物的负面后果”）时，fNIRS 测量了前额叶皮层的活动。
参与者（N=32，女性占 62.5%；BMI 38.6±7.1；年龄 43.5±13.4 岁）的 BMI 均大于 30 kg/m2。18 名成年人（女性占 67.0%；BMI 38.2±7.6）报告有 BE（过去 3 个月内有≥12 次 BE 发作）。对照组由 14 名否认 BE 的成年人组成（女性占 64.0%；BMI 39.2±6.6）。在整个样本中，混合模型显示，与观看（放松）条件相比，在整个样本中，双侧内侧额上回、背外侧区域和额中回（光导 5、7、9、10、11 和 12）在渴望和抵制期间存在显著的小范围过度激活。在 BE 组和对照组之间，神经激活没有统计学上的显著差异。此外，在神经激活方面，组与条件之间没有显著的相互作用。
在肥胖成年人中，BE 状态与食物相关再评价任务中抑制性前额叶皮层区域的激活无差异。需要进一步进行研究，样本量更大，纳入没有肥胖的成年人，并使用具有行为和认知成分的抑制范式。
III 级：来源于精心设计的队列或病例对照分析研究的证据。
#NCT03113669，日期为 2017 年 4 月 13 日。
