Hege M A, Stingl K T, Kullmann S, Schag K, Giel K E, Zipfel S, Preissl H
1] Institute of Medical Psychology and Behavioural Neurobiology/fMEG Center, University Tübingen, Tübingen, Germany [2] Graduate School of Neural and Behavioural Sciences, International Max Planck Research School, University Tübingen, Tübingen, Germany.
1] Institute of Medical Psychology and Behavioural Neurobiology/fMEG Center, University Tübingen, Tübingen, Germany [2] Department of Neonatology, University Children's Hospital Tübingen, Tübingen, Germany.
Int J Obes (Lond). 2015 Feb;39(2):353-60. doi: 10.1038/ijo.2014.99. Epub 2014 Jun 9.
A subgroup of overweight and obese people is characterized by binge eating disorder (BED). Increased impulsivity has been suggested to cause binge eating and subsequent weight gain. In the current study, neuronal correlates of increased impulsivity in binge eating disorder during behavioral response inhibition were investigated.
Magnetic brain activity and behavioral responses of 37 overweight and obese individuals with and without diagnosed BED were recorded while performing a food-related visual go-nogo task. Trait impulsivity was assessed with the Barratt Impulsiveness Scale (BIS-11).
Specifically, increased attentional impulsiveness (a subscale of the BIS-11) in BED was related to decreased response inhibition performance and hypoactivity in the prefrontal control network, which was activated when response inhibition was required. Furthermore, participants with BED showed a trend for a food-specific inhibition performance decline. This was possibly related to the absence of a food-specific activity increase in the prefrontal control network in BED, as observed in the control group. In addition, an increase in activity related to the actual button press during prepotent responses and alterations in visual processing were observed.
Our results suggest an attentional impulsiveness-related attenuation in response inhibition performance in individuals with BED. This might have been related to increased reward responsiveness and limited resources to activate the prefrontal control network involved in response inhibition. Our results substantiate the importance of neuronal markers for investigating prevention and treatment of obesity, especially in specific subgroups at risk such as BED.
超重和肥胖人群中的一个亚组具有暴饮暴食症（BED）的特征。有人提出，冲动性增加会导致暴饮暴食及随后的体重增加。在本研究中，我们调查了行为反应抑制过程中暴饮暴食症患者冲动性增加的神经相关性。
对37名超重和肥胖个体（其中部分被诊断患有BED，部分未患）进行与食物相关的视觉“是/否”任务时，记录其脑磁活动和行为反应。用巴拉特冲动性量表（BIS-11）评估特质冲动性。
具体而言，BED患者注意力冲动性（BIS-11的一个子量表）增加与反应抑制表现下降以及前额叶控制网络活动减退有关，前额叶控制网络在需要反应抑制时被激活。此外，患有BED的参与者表现出食物特异性抑制表现下降的趋势。这可能与BED患者前额叶控制网络中未出现食物特异性活动增加有关，而对照组中观察到了这种增加。另外，在优势反应期间观察到与实际按键相关的活动增加以及视觉处理的改变。
我们的结果表明，BED患者的反应抑制表现存在与注意力冲动性相关的减弱。这可能与奖励反应性增加以及激活参与反应抑制的前额叶控制网络的资源有限有关。我们的结果证实了神经标志物在研究肥胖预防和治疗中的重要性，特别是在有风险的特定亚组如BED中。
