Center for Orthodontics and Pediatric Dentistry, Norrköping, Public Dental Service Östergötland, Norrköping, Sweden.
Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Eur J Orthod. 2023 May 31;45(3):295-307. doi: 10.1093/ejo/cjad009.
Malocclusions in adolescents might have a negative impact on oral health-related quality of life (OHRQoL). Potential confounding variables (confounders) such as age, gender, caries, and socioeconomic status may skew the real relationship between malocclusions and OHRQoL.
To analyse the effect of malocclusions in adolescents on OHRQoL, when controlled for potential confounders.
Five databases (PubMed, Cochrane Library, Cinahl, Scopus, and Web of Science) were searched up to 15 June 2022.
Studies in which OHRQoL in 10-19-year olds with and without malocclusions were compared.
Screening, data extraction, and quality assessments were performed by four investigators independently. Risk of bias was assessed according to the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) guidelines. To be included, studies had to control for confounders. Certainty of evidence was assessed with GRADE.
Thirteen cross-sectional studies with low and moderate risk of bias were included in the qualitative synthesis. Four of these were also included in the quantitative synthesis (meta-analysis). The 13 studies in the qualitative synthesis displayed a large variation among the indices used for malocclusion ratings, as well as in instruments measuring OHRQoL. There was moderate quality of evidence that malocclusions have a negative effect on OHRQoL. The four articles included in the quantitative synthesis (meta-analysis) measured malocclusions with DAI and OHRQoL with CPQ 11-14 short form. There was moderate quality of evidence that malocclusions have a negative effect on OHRQoL (RR/PR 1.15, 95% CI 1.12-1.18, 3672 participants).
There is moderate quality of evidence that malocclusions in adolescents have a negative impact on OHRQoL, after taking relevant confounders into consideration. Future studies should ideally use standardized measures for malocclusion ratings and OHRQoL.
PROSPERO. CRD42020186152.
青少年错颌畸形可能对口腔健康相关生活质量（OHRQoL）产生负面影响。年龄、性别、龋齿和社会经济地位等潜在混杂因素（混杂因素）可能会扭曲错颌畸形与 OHRQoL 之间的真实关系。
分析在控制潜在混杂因素的情况下，青少年错颌畸形对 OHRQoL 的影响。
截至 2022 年 6 月 15 日，检索了 5 个数据库（PubMed、Cochrane Library、Cinahl、Scopus 和 Web of Science）。
比较有和无错颌畸形的 10-19 岁青少年的 OHRQoL 的研究。
四名研究者独立进行了筛选、数据提取和质量评估。根据瑞典卫生技术评估和社会服务评估署（SBU）指南评估偏倚风险。纳入的研究必须控制混杂因素。使用 GRADE 评估证据的确定性。
纳入了 13 项偏倚风险低至中度的横断面研究，进行了定性综合分析。其中 4 项还进行了定量综合分析（荟萃分析）。定性综合分析中的 13 项研究在错颌畸形评分的指标以及测量 OHRQoL 的工具方面存在很大差异。有中等质量的证据表明错颌畸形对 OHRQoL 有负面影响。纳入定量综合分析（荟萃分析）的 4 篇文章使用 DAI 测量错颌畸形，使用 CPQ 11-14 短表测量 OHRQoL。有中等质量的证据表明错颌畸形对 OHRQoL 有负面影响（RR/PR 1.15，95%CI 1.12-1.18，3672 名参与者）。
在考虑相关混杂因素后，有中等质量的证据表明青少年的错颌畸形对 OHRQoL 有负面影响。未来的研究理想情况下应使用标准化的错颌畸形评分和 OHRQoL 测量方法。
PROSPERO。CRD42020186152。
