热适应大鼠的甲状腺状态与去甲肾上腺素诱导的调节性产热
Thyroid status and noradrenaline-induced regulatory thermogenesis in heat acclimated rats.
作者信息
Arieli A, Chinet A
出版信息
Horm Metab Res. 1986 Feb;18(2):103-6. doi: 10.1055/s-2007-1012242.
Adjustments of the obligatory and regulatory thermogenesis upon heat acclimation (34 degrees C) and perchlorate treatment were observed in male rats. Resting oxygen consumption measured at neutral temperature was reduced, with respect to control, by 23, 27, and 34% in heat acclimated, perchlorate treated, and heat acclimated-perchlorate treated rats, respectively. Administration of 0.4 mg NA/kg increased oxygen consumption by 40, 30, 5 and 1% above resting level in control, heat acclimated, perchlorate treated, and heat acclimated-perchlorate treated rats, respectively. Whereas significant interaction was found between the effects of thyroid hormones and acclimation temperature on obligatory thermogenesis, the interaction of these factors on regulatory thermogenesis was not statistically significant. Still, hypothyroidism may be considered a thermoregulatory advantage during chronic heat exposure.
在雄性大鼠中观察了热适应（34摄氏度）和高氯酸盐处理后 obligatory 和 regulatory 产热的调整情况。在中性温度下测量的静息耗氧量，与对照组相比，热适应、高氯酸盐处理以及热适应-高氯酸盐处理的大鼠分别降低了23%、27%和34%。给予0.4毫克去甲肾上腺素/千克后，对照组、热适应、高氯酸盐处理以及热适应-高氯酸盐处理的大鼠的耗氧量分别比静息水平增加了40%、30%、5%和1%。虽然甲状腺激素和适应温度对 obligatory 产热的影响之间存在显著相互作用，但这些因素对 regulatory 产热的相互作用在统计学上并不显著。尽管如此，甲状腺功能减退在慢性热暴露期间可能被认为是一种体温调节优势。
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