Pokharel Yashashwi, Macedo Francisco Y, Nambi Vijay, Martin Seth S, Nasir Khurram, Wong Nathan D, Boone Jeffrey, Roberts Arthur J, Ballantyne Christie M, Virani Salim S
Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston, Texas.
Clin Cardiol. 2014 Jul;37(7):402-7. doi: 10.1002/clc.22270. Epub 2014 Mar 19.
Neck circumference (NC) is associated with metabolic syndrome (MetS) in the general population. It is not known if NC is associated with MetS and subclinical atherosclerosis in retired National Football League (NFL) players.
We hypothesized that NC is associated with MetS and subclinical atherosclerosis (assessed as coronary artery calcium [CAC] and carotid artery plaque [CAP]) in retired NFL players.
NC was measured midway between the midcervical spine and midanterior neck in 845 retired NFL players. CAC presence was defined as total CAC score >0. CAP was defined as carotid plaque of at least 50% greater than that of the surrounding vessel wall, with a minimal thickness of at least 1.2 mm on carotid ultrasound. Logistic regression analysis was used for the association of NC with CAC or CAP.
Of the participants, 21% had MetS. CAC and CAP were present in 62% and 56%, respectively. Those with MetS had a higher median NC than those without MetS (17 vs 16 inches, P < 0.0001). NC was not associated with the presence of CAC or CAP in an unadjusted model and after adjusting for age, race, and cardiometabolic risk factors (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 0.94-1.31 for CAC; OR: 0.96, 95% CI: 0.82-1.12 for CAP per 1-standard deviation increase in NC [3.8 inches]). The results were similar when the predictor variable was NC indexed to body mass index.
In retired NFL players with a high prevalence of CAC and CAP, NC was not associated with coronary or carotid subclinical atherosclerosis. NC may not be the most appropriate risk marker for atherosclerosis.
在普通人群中，颈围（NC）与代谢综合征（MetS）相关。目前尚不清楚NC是否与退役的美国国家橄榄球联盟（NFL）球员的MetS及亚临床动脉粥样硬化有关。
我们假设NC与退役NFL球员的MetS及亚临床动脉粥样硬化（通过冠状动脉钙化[CAC]和颈动脉斑块[CAP]评估）相关。
在845名退役NFL球员中，于颈椎中部和颈部前方中部之间的中点测量NC。CAC的存在定义为总CAC评分>0。CAP定义为颈动脉斑块比周围血管壁至少大50%，且在颈动脉超声检查中最小厚度至少为1.2毫米。采用逻辑回归分析NC与CAC或CAP的关联。
参与者中，21%患有MetS。CAC和CAP的存在率分别为62%和56%。患有MetS的参与者的NC中位数高于未患MetS的参与者（17英寸对16英寸，P<0.0001）。在未调整模型中以及在调整年龄、种族和心脏代谢危险因素后，NC与CAC或CAP的存在均无关联（每NC增加1个标准差[3.8英寸]，CAC的比值比[OR]：1.11，95%置信区间[CI]：0.94 - 1.31；CAP的OR：0.96，95%CI：0.82 - 1.12）。当预测变量为根据体重指数校正的NC时，结果相似。
在CAC和CAP患病率较高的退役NFL球员中，NC与冠状动脉或颈动脉亚临床动脉粥样硬化无关。NC可能不是动脉粥样硬化最合适的风险标志物。
