School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
BMC Public Health. 2023 Mar 30;23(1):611. doi: 10.1186/s12889-023-15496-z.
To systematically evaluate the association between maternal active smoking during pregnancy and Tourette syndrome (TS), chronic tic disorder (CTD), and developmental coordination disorder (DCD) in children, and to provide evidence-based medical references to reduce the incidence of neurodevelopmental disorders in children.
We searched PubMed, Web of Science, Embase, and Cochrane Library to obtain relevant articles published before 4 August 2021. Two reviewers independently assessed the articles for eligibility and extracted data.
We included eight studies involving a total of 50,317 participants (3 cohort, 3 case-control, and 2 cross-sectional studies). The pooled effect estimates suggested that prenatal maternal active smoking is related to an increased risk of neurodevelopmental disorders (OR = 1.91, 95% CI: 1.30-2.80), especially DCD (OR = 2.25, 95% CI: 1.35-3.75). Maternal active smoking during pregnancy is not associated with TS (OR = 1.07, 95% CI: 0.66-1.73) in children.
In this meta-analysis, we found evidence for a correlation between active smoking exposure in pregnant women and neurodevelopmental disorders in children. Owing to the differences in sample size, smoking categories and diagnostic methods, further research is needed to validate our results.
系统评估母亲怀孕期间主动吸烟与儿童抽动秽语综合征（TS）、慢性抽动障碍（CTD）和发育性协调障碍（DCD）的关联，为降低儿童神经发育障碍的发生率提供循证医学参考。
我们检索了 PubMed、Web of Science、Embase 和 Cochrane Library，以获取截至 2021 年 8 月 4 日发表的相关文章。两位评审员独立评估文章的纳入资格并提取数据。
我们纳入了 8 项研究，共涉及 50317 名参与者（3 项队列研究、3 项病例对照研究和 2 项横断面研究）。汇总效应估计表明，产前母亲主动吸烟与神经发育障碍（OR=1.91，95%CI：1.30-2.80），特别是 DCD（OR=2.25，95%CI：1.35-3.75）的风险增加有关。母亲怀孕期间主动吸烟与儿童 TS（OR=1.07，95%CI：0.66-1.73）无关。
在这项荟萃分析中，我们发现孕妇暴露于主动吸烟与儿童神经发育障碍之间存在关联的证据。由于样本量、吸烟类别和诊断方法的差异，需要进一步的研究来验证我们的结果。
