儿童抽动障碍合并过敏性疾病的常见影响因素及可能机制综述

A review of common influencing factors and possible mechanisms associated with allergic diseases complicating tic disorders in children.

作者信息

Zhang Panpan, Zheng Zhimin, Sun Hao, Gao Tieying, Xiao Xuwu

机构信息

Department of Child Health, Dalian Municipal Women and Children's Medical Center (Group), Dalian, Liaoning, China.

Dalian Medical University, Dalian, Liaoning, China.

出版信息

Front Pediatr. 2024 Jun 18;12:1360420. doi: 10.3389/fped.2024.1360420. eCollection 2024.

Abstract

Over the past few decades, the incidence of childhood allergic diseases has increased globally, and their impact on the affected child extends beyond the allergy itself. There is evidence of an association between childhood allergic diseases and the development of neurological disorders. Several studies have shown a correlation between allergic diseases and tic disorders (TD), and allergic diseases may be an important risk factor for TD. Possible factors influencing the development of these disorders include neurotransmitter imbalance, maternal anxiety or depression, gut microbial disorders, sleep disturbances, maternal allergic status, exposure to tobacco, and environmental factors. Moreover, gut microbial disturbances, altered immunological profiles, and DNA methylation in patients with allergic diseases may be potential mechanisms contributing to the development of TD. An in-depth investigation of the relationship between allergic diseases and TD in children will be important for preventing and treating TD.

摘要

在过去几十年中,儿童过敏性疾病的发病率在全球范围内有所上升,其对患病儿童的影响不仅限于过敏本身。有证据表明儿童过敏性疾病与神经疾病的发生之间存在关联。多项研究显示过敏性疾病与抽动障碍(TD)之间存在相关性,过敏性疾病可能是TD的一个重要风险因素。影响这些疾病发生的可能因素包括神经递质失衡、母亲焦虑或抑郁、肠道微生物紊乱、睡眠障碍、母亲过敏状态、接触烟草以及环境因素。此外,过敏性疾病患者的肠道微生物紊乱、免疫谱改变和DNA甲基化可能是导致TD发生的潜在机制。深入研究儿童过敏性疾病与TD之间的关系对于预防和治疗TD具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d9/11218626/c0f4c3ba5adf/fped-12-1360420-g001.jpg

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