Ayubi Erfan, Mansori Kamyar, Doosti-Irani Amin
Health Promotion Research Center, Zahedan, Iran.
Department of Community Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Obstet Gynecol Sci. 2021 Jan;64(1):1-12. doi: 10.5468/ogs.20252. Epub 2020 Dec 29.
Current studies have controversial reports about the effect of maternal smoking during pregnancy (MSDP) on the risk of psychiatric disorders among offspring. The purpose of this systematic review and meta-analysis was to assess the effect of MSDP on the risk of Tourette syndrome (TS) and chronic tic disorders (CTD) among offspring. A systematic search using PubMed, Scopus, and Web of Science was conducted up to July 2019 to retrieve potential studies in English. Fixed and random-effects meta-analyses was performed to estimate pooled relative risk (RR) with 95% confidence interval (CI) according to heterogeneity. The methodological quality of the included studies was evaluated using the Newcastle-Ottawa Scale. Heterogeneity among studies was explored using the I2 statistic. Of the 641 studies from the initial search, 7 were included in the quantitative synthesis (3 cohort and 4 case control studies). Overall, MSDP increased the risk of TS and CTD among the offspring by 35% (pooled RR, 1.35; 95% CI, 1.17-1.56; I2 =45.8%; P-value=0.08). The results of this meta-analysis revealed that there is a significant association between MSDP and the risk of TS and CTD in offspring, and MSDP may be considered a potential risk factor for TS and CTD.
目前的研究对于孕期母亲吸烟（MSDP）对后代患精神疾病风险的影响存在相互矛盾的报道。本系统评价和荟萃分析的目的是评估MSDP对后代患抽动秽语综合征（TS）和慢性抽动障碍（CTD）风险的影响。截至2019年7月，通过PubMed、Scopus和Web of Science进行了系统检索，以检索英文的潜在研究。根据异质性，采用固定效应和随机效应荟萃分析来估计合并相对风险（RR）及95%置信区间（CI）。使用纽卡斯尔-渥太华量表评估纳入研究的方法学质量。使用I2统计量探索研究间的异质性。在初步检索的641项研究中，有7项纳入了定量合成（3项队列研究和4项病例对照研究）。总体而言，MSDP使后代患TS和CTD的风险增加了35%（合并RR，1.35；95%CI，1.17-1.56；I2 =45.8%；P值=0.08）。该荟萃分析的结果表明，MSDP与后代患TS和CTD的风险之间存在显著关联，MSDP可能被视为TS和CTD的潜在风险因素。
