Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.
Department of Oncology, Shandong First Medical University, Jinan, China.
Cancer Med. 2023 May;12(10):11570-11588. doi: 10.1002/cam4.5778. Epub 2023 Mar 31.
Ferritin, a ubiquitously distributed iron storage protein, can specifically target tumor cells through transferrin receptor 1. Due to its rearrangeable nanocage structure, ferritin can be loaded with anticancer drugs. Combined with amino acid modifications on the outer- and/or inner-spaces of the nanocage, ferritins can be further coupled with antigens, antibodies, and nucleotide sequences. Since ferritin is naturally presented in the human body, when used in vivo, ferritin exhibits good biocompatibility, and no immunogenic response occurs. These makes ferritin an ideal nanocarrier which shows broad application prospects in cancer therapy.
In this study, to find articles, a search was made in PubMed with the keywords ferritin, drug delivery, drug delivery, and cancer treatment.
According to the investigation, some studies suggest that ferritin can be loaded with drugs and targeted for delivery to tumor tissue. Therefore, ferritin nanocarriers loaded with drugs can be used in chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT) and immunotherapy. Importantly, the specific targeting of ferritin nanocarriers to tumor cells increases the effectiveness of related therapies and reduces side effects.
We conclude in this paper that the superior properties of ferritin nanocarriers as an emerging drug delivery system make them a promising cancer treatment strategy. In the future, it is worth conducting clinical trials to further investigate the safety and efficacy of ferritin nanocarriers in patients.
铁蛋白是一种广泛分布的铁储存蛋白，可通过转铁蛋白受体 1 特异性靶向肿瘤细胞。由于其可重构的纳米笼结构，铁蛋白可以负载抗癌药物。通过对纳米笼的外腔和/或内腔进行氨基酸修饰，铁蛋白可以进一步与抗原、抗体和核苷酸序列结合。由于铁蛋白在人体内天然存在，因此在体内使用时，铁蛋白表现出良好的生物相容性，不会发生免疫反应。这使得铁蛋白成为一种理想的纳米载体，在癌症治疗中有广泛的应用前景。
在这项研究中，为了寻找相关文章，我们在 PubMed 上使用了铁蛋白、药物传递、药物传递和癌症治疗等关键词进行了搜索。
根据调查，一些研究表明铁蛋白可以负载药物并靶向递送到肿瘤组织。因此，负载药物的铁蛋白纳米载体可用于化疗、光动力疗法（PDT）、光热疗法（PTT）和免疫疗法。重要的是，铁蛋白纳米载体对肿瘤细胞的特异性靶向作用提高了相关治疗的效果，并降低了副作用。
本文得出结论，铁蛋白作为一种新兴的药物传递系统，具有优越的性能，使其成为一种很有前途的癌症治疗策略。在未来，值得进行临床试验，以进一步研究铁蛋白纳米载体在患者中的安全性和疗效。
