Wang Wan, Xu Cong, Wang Qingyun, Hussain Muhammad Altaf, Wang Changyuan, Hou Juncai, Jiang Zhanmei
Key Laboratory of Dairy Science, College of Food Science, Northeast Agricultural University, Harbin 150030, China.
Beidahuang Wondersun Dairy Co., Ltd., Harbin 150090, China.
J Agric Food Chem. 2023 Mar 31. doi: 10.1021/acs.jafc.2c07081.
Alcoholic liver disease (ALD) has emerged as an important public health problem in the world. The polyphenols, protein, peptides, and polysaccharides have attracted attention for prevention or treatment of ALD. Therefore, this paper reviews the pathogenesis of ALD, the relationship between polyphenols, peptides, polysaccharides, and ALD, and expounds the mechanism of gut microbiota on protecting ALD. It is mainly found that the hydroxyl group of polyphenols endows it with antioxidation to protect ALD. The ALD protection of bioactive peptides is related to amino acid composition. The ALD protection of polysaccharides is related to the primary structure. Meanwhile, polyphenols, protein, peptides, and polysaccharides prevent or treat ALD by antioxidation, anti-inflammatory, antiapoptosis, lipid metabolism, and gut microbiota regulation. This contribution provides updated information on polyphenols, protein, peptides, and polysaccharides in response to ALD, which will not only facilitate the development of novel bioactive components but also the future application of functional food raw materials will be promoted.
酒精性肝病（ALD）已成为全球一个重要的公共卫生问题。多酚、蛋白质、肽和多糖在预防或治疗ALD方面受到关注。因此，本文综述了ALD的发病机制、多酚、肽、多糖与ALD的关系，并阐述了肠道微生物群对ALD的保护机制。主要发现多酚的羟基赋予其抗氧化能力以保护ALD。生物活性肽对ALD的保护作用与氨基酸组成有关。多糖对ALD的保护作用与一级结构有关。同时，多酚、蛋白质、肽和多糖通过抗氧化、抗炎、抗凋亡、脂质代谢和肠道微生物群调节来预防或治疗ALD。本文提供了关于多酚、蛋白质、肽和多糖应对ALD的最新信息，这不仅将促进新型生物活性成分的开发，还将推动功能性食品原料的未来应用。
