诱导抑制性细胞中的佐剂。

Adjuvants in the induction of suppressor cells.

作者信息

Neta R, Salvin S B

出版信息

Infect Immun. 1979 Feb;23(2):360-5. doi: 10.1128/iai.23.2.360-365.1979.

DOI:10.1128/iai.23.2.360-365.1979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414173/

Abstract

The effect of different mycobacterial adjuvants on the parameters of delayed hypersensitivity was investigated in strain 13 guinea pigs. The composition of the tubercle bacilli and the type of vehicle in which the antigen was presented determined the presence and extent of suppressor cell activity. When antigen was introduced in complete Freund adjuvant, both adherent and nonadherent cells had suppressive properties, with the suppressive effect demonstrable in vitro from 1 to 5 weeks after sensitization. Suppressor activity was indicated in vivo by a reduction of delayed footpad hypersensitivity in animals presensitized with complete Freund adjuvant.

摘要

在13号品系豚鼠中研究了不同分枝杆菌佐剂对迟发型超敏反应参数的影响。结核杆菌的组成以及抗原呈现时所用载体的类型决定了抑制细胞活性的存在及程度。当抗原用完全弗氏佐剂引入时，贴壁细胞和非贴壁细胞均具有抑制特性，致敏后1至5周在体外可证实其抑制作用。在用完全弗氏佐剂预致敏的动物中，足垫迟发型超敏反应降低表明体内存在抑制活性。

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