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1
Suppression of BCG cell wall-induced delayed-type hypersensitivity by BCG pre-treatment. II. Induction of suppressor T cells by heat-killed BCG injection.卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用。II. 热灭活卡介苗注射诱导抑制性T细胞
Immunology. 1982 Apr;45(4):655-61.
2
Suppression of BCG cell wall-induced delayed-type hypersensitivity by pretreatment with killed BCG: induction of nonspecific suppressor T cells by the adjuvant portion (MDP) and of specific suppressor T cells by the antigen portion (TAP).用灭活卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用：佐剂部分（MDP）诱导非特异性抑制性T细胞，抗原部分（TAP）诱导特异性抑制性T细胞。
J Immunol. 1984 Jun;132(6):2790-5.
3
Non-specific suppression of delayed-type hypersensitivity by intrathymic injection of killed bacteria.胸腺内注射死菌对迟发型超敏反应的非特异性抑制作用
Thymus. 1984;6(1-2):79-87.
4
Suppression of BCG cell wall induced delayed-type hypersensitivity by BCG pre-treatment. I. Induction of adherent suppressor cells by live BCG injection and their characterization.卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用。I. 活卡介苗注射诱导黏附性抑制细胞及其特性研究
Immunology. 1981 Feb;42(2):259-66.
5
Migration of natural suppressor cells from bone marrow to peritoneal cavity by live BCG.活卡介苗介导自然抑制细胞从骨髓迁移至腹腔。
J Immunol. 1985 Dec;135(6):3661-8.
6
Analysis of defective delayed-type hypersensitivity in autoimmune mice bearing lpr gene.携带lpr基因的自身免疫小鼠中缺陷性迟发型超敏反应的分析
Clin Exp Immunol. 1986 Jan;63(1):87-94.
7
[Analysis of interferon-gamma production in killed BCG-pretreated mice after stimulation with staphylococcal enterotoxin A].[用葡萄球菌肠毒素A刺激卡介苗预处理的灭活小鼠后γ干扰素产生的分析]
Kekkaku. 1989 Aug;64(8):499-509.
8
Effect of Bacillus Calmette-Guérin on the in vitro generation of cytotoxic T lymphocytes. II. Role of interleukin-1-like factors and of soluble suppressor factors.卡介苗对细胞毒性T淋巴细胞体外生成的影响。II. 白细胞介素-1样因子和可溶性抑制因子的作用。
Immunology. 1985 Oct;56(2):235-43.
9
[Induction of suppressor adherent cells by injecting heavy dose of live BCG. I. In vitro analysis of suppression of BCG cell wall induced delayed type hypersensitivity (author's transl)].[通过注射大剂量活卡介苗诱导抑制性黏附细胞。I. 卡介苗细胞壁诱导的迟发型超敏反应抑制的体外分析（作者译）]
Kekkaku. 1980 Sep;55(9):401-6.
10
Evaluation of bovine cutaneous delayed-type hypersensitivity (DTH) to various test antigens and a mitogen using several adjuvants.使用多种佐剂评估牛对各种测试抗原和一种丝裂原的皮肤迟发型超敏反应（DTH）。
Vet Immunol Immunopathol. 2005 Mar 10;104(1-2):45-58. doi: 10.1016/j.vetimm.2004.10.006.

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VapC12 ribonuclease toxin modulates host immune response during infection.VapC12 核糖核酸酶毒素在感染过程中调节宿主免疫反应。
Front Immunol. 2024 Mar 7;15:1302163. doi: 10.3389/fimmu.2024.1302163. eCollection 2024.
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Mycobacterium tuberculosis exploits MPT64 to generate myeloid-derived suppressor cells to evade the immune system.结核分枝杆菌利用 MPT64 产生髓系来源的抑制细胞来逃避免疫系统。
Cell Mol Life Sci. 2022 Oct 25;79(11):567. doi: 10.1007/s00018-022-04596-5.
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Effective Host-Directed Therapy for Tuberculosis by Depletion of Myeloid-Derived Suppressor Cells and Related Cells Using a Diphtheria Toxin Fusion Protein.利用白喉毒素融合蛋白耗竭髓系来源的抑制细胞和相关细胞实现结核病的有效宿主导向治疗。
J Infect Dis. 2021 Dec 1;224(11):1962-1972. doi: 10.1093/infdis/jiab235.
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The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis.髓系来源抑制细胞在结核病中的新作用。
Front Immunol. 2019 Apr 30;10:917. doi: 10.3389/fimmu.2019.00917. eCollection 2019.
5
Influence of subclass-specific anti-idiotypic antibodies on the kinetics of the immune response to BCG.亚类特异性抗独特型抗体对卡介苗免疫反应动力学的影响。
Immunology. 1984 Aug;52(4):697-702.
6
Strain differences in lung granuloma formation in response to a BCG cell-wall vaccine in mice. Failure of antigen presentation by low-responder macrophages.小鼠对卡介苗细胞壁疫苗产生肺部肉芽肿形成的品系差异。低反应性巨噬细胞抗原呈递功能的缺陷。
Immunology. 1983 Nov;50(3):423-31.
7
Suppressor T cells in BCG-treated mice interfere with an in vivo specific antitumoral immune response.卡介苗治疗小鼠中的抑制性T细胞会干扰体内特异性抗肿瘤免疫反应。
Br J Cancer. 1984 Jun;49(6):759-68. doi: 10.1038/bjc.1984.119.
8
Genetic aspects of innate resistance and acquired immunity to mycobacteria in inbred mice.近交系小鼠对分枝杆菌先天抗性和获得性免疫的遗传方面
Springer Semin Immunopathol. 1988;10(4):319-36. doi: 10.1007/BF02053844.
9
Depression of delayed-type hypersensitivity in mice with hypothalamic lesion induced by monosodium glutamate: involvement of neuroendocrine system in immunomodulation.谷氨酸钠诱导下丘脑损伤小鼠迟发型超敏反应的抑制：神经内分泌系统在免疫调节中的作用。
Immunology. 1986 Jul;58(3):389-95.
10
Induction by an immunogenic immunomodulating agent of nonspecific T cell suppression of lymphocyte responsiveness in MLR but not of antibody production.免疫原性免疫调节剂诱导对混合淋巴细胞反应中淋巴细胞反应性的非特异性T细胞抑制，但不诱导抗体产生。
Cancer Immunol Immunother. 1988;26(2):153-60. doi: 10.1007/BF00205609.

本文引用的文献

1
Suppression of BCG cell wall induced delayed-type hypersensitivity by BCG pre-treatment. I. Induction of adherent suppressor cells by live BCG injection and their characterization.卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用。I. 活卡介苗注射诱导黏附性抑制细胞及其特性研究
Immunology. 1981 Feb;42(2):259-66.
2
Development of suppressor T cells in mice heavily infected with mycobacteria.在严重感染分枝杆菌的小鼠中抑制性T细胞的发育
Immunology. 1980 Mar;39(3):367-73.
3
Adjuvant-induced nonspecific supressor cells: in vitro and in vivo studies.佐剂诱导的非特异性抑制细胞：体内外研究
Cell Immunol. 1980 Aug 1;53(2):225-35. doi: 10.1016/0008-8749(80)90324-x.
4
Induction of suppressor T cells in delayed-type hypersensitivity to Mycobacterium bovis BCG in low-responder mice.低反应性小鼠对牛分枝杆菌卡介苗迟发型超敏反应中抑制性T细胞的诱导。
Infect Immun. 1980 May;28(2):331-5. doi: 10.1128/iai.28.2.331-335.1980.
5
Suppression of T-cell responses to histocompatibility antigens by BCG pre-treatment.卡介苗预处理对T细胞针对组织相容性抗原反应的抑制作用。
Immunology. 1980 Feb;39(2):263-8.
6
Immunogenicity of cell walls from various mycobacteria against airborne tuberculosis in mice.不同分枝杆菌细胞壁对小鼠空气传播型结核病的免疫原性
J Bacteriol. 1968 Jun;95(6):2000-4. doi: 10.1128/jb.95.6.2000-2004.1968.
7
Depression of the T cell phenomenon of contact sensitivity by T cells from unresponsive mice.无反应小鼠的T细胞对接触敏感性T细胞现象的抑制作用。
Nature. 1973 Jul 27;244(5413):227-8. doi: 10.1038/244227a0.
8
Tolerance and contact sensitivity to DNFB in mice. 3. Transfer of tolerance with "suppressor T cells".小鼠对二硝基氟苯的耐受性和接触敏感性。3. 用“抑制性T细胞”转移耐受性
J Immunol. 1974 Oct;113(4):1230-6.
9
Biological effects of the adjuvant Corynebacterium parvum. II. Evidence for macrophage-T-cell interaction.佐剂短小棒状杆菌的生物学效应。II. 巨噬细胞与T细胞相互作用的证据。
Cell Immunol. 1972 Nov;5(3):469-79. doi: 10.1016/0008-8749(72)90073-1.
10
Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients.胸腺在免疫耐受中的作用。十、转移至正常受体的抗原刺激大鼠胸腺细胞的“抑制”活性。
J Immunol. 1973 May;110(5):1290-9.

卡介苗预处理对卡介苗细胞壁诱导的迟发型超敏反应的抑制作用。II. 热灭活卡介苗注射诱导抑制性T细胞

Suppression of BCG cell wall-induced delayed-type hypersensitivity by BCG pre-treatment. II. Induction of suppressor T cells by heat-killed BCG injection.

作者信息

Kato K, Yamamoto K

出版信息

Immunology. 1982 Apr;45(4):655-61.

PMID:6175566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555398/
Abstract

Previous intravenous (i.v.) injection of heat-killed Bacillus Calmette-Guérin (BCG) in mice produced a suppression of delayed-type hypersensitivity (DTH) induced with oil-treated BCG cell walls. This phenomenon was analysed by the macrophage migration inhibition (MI) test in which non-adherent spleen cells from mice which had been injected with heat-killed BCG (K-Non-ad. cells) were mixed with peritoneal exudate cells from BCG cell wall-immunized mice (effector-PEC). The test showed that the K-Non-ad. cells suppressed the MI activity in the effector-PEC, which indicated that the suppressor cells were induced in the spleen by the heat-killed BCG injections. Moreover, the suppressive effect of the K-Non-ad. cells disappeared after treatment with anti-brain associated theta serum (BA theta) and guinea-pig complement, and operated across the H-2 barrier. The suppressor cells inhibited the production or release of the migration inhibition factor from the BCG cell wall-sensitized cells in the presence of the specific antigen, purified protein derivatives (PPD). It was concluded that the injections of heat-killed BCG produced antigen non-specific suppressor T cells in DTH suppression.

摘要

先前给小鼠静脉注射热灭活卡介苗（BCG）可抑制经油处理的卡介苗细胞壁诱导的迟发型超敏反应（DTH）。通过巨噬细胞迁移抑制（MI）试验对该现象进行了分析，即将注射过热灭活卡介苗的小鼠的非黏附脾细胞（K - 非黏附细胞）与经卡介苗细胞壁免疫的小鼠的腹腔渗出细胞（效应 - PEC）混合。试验表明，K - 非黏附细胞抑制了效应 - PEC中的MI活性，这表明热灭活卡介苗注射可在脾脏中诱导出抑制细胞。此外，用抗脑相关θ血清（BAθ）和豚鼠补体处理后，K - 非黏附细胞的抑制作用消失，且这种抑制作用可跨越H - 2屏障。在存在特异性抗原纯化蛋白衍生物（PPD）的情况下，抑制细胞抑制了卡介苗细胞壁致敏细胞产生或释放迁移抑制因子。得出的结论是，注射热灭活卡介苗在DTH抑制中产生了抗原非特异性抑制性T细胞。