弗氏佐剂预处理对迟发型超敏反应的抑制作用。II. 该现象的机制
Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. II. Mechanism of the phenomenon.
作者信息
Allwood G G, Asherson G L
出版信息
Clin Exp Immunol. 1971 Aug;9(2):259-66.
Recipient guinea-pigs pretreated with Freund's complete adjuvant alone show depressed 4 hr (Arthus) reactions following passive transfer of antiserum to bovine γ-globulin and human serum albumin. Recipient outbred guinea-pigs and inbred rats also show depressed 24 hr delayed reactions following passive transfer of immune peritoneal exudate cells and serum. This indicates that Freund's complete adjuvant depresses certain inflammatory responses. Donor guinea-pigs and inbred rats pretreated with FCA alone and then immunized with BGG in FCA transfer smaller 24 hr reactions to normal recipients than comparable donor animals which have not been pretreated with FCA. This suggests that pretreatment with FCA depresses the central state of delayed hypersensitivity which normally follows immunization with BGG in FCA. These two findings may explain why pretreatment with FCA depresses the 4 and 24 hr skin reactions which otherwise follow immunization with antigen in FCA.
仅用弗氏完全佐剂预处理的受体豚鼠，在被动转移抗牛γ球蛋白和人血清白蛋白的抗血清后，4小时（阿瑟斯）反应受到抑制。受体远交豚鼠和近交大鼠在被动转移免疫腹膜渗出细胞和血清后，24小时延迟反应也受到抑制。这表明弗氏完全佐剂会抑制某些炎症反应。仅用弗氏完全佐剂预处理然后用弗氏完全佐剂中的牛γ球蛋白免疫的供体豚鼠和近交大鼠，向正常受体转移的24小时反应比未用弗氏完全佐剂预处理的可比供体动物小。这表明用弗氏完全佐剂预处理会抑制通常在弗氏完全佐剂中用牛γ球蛋白免疫后出现的迟发型超敏反应的中枢状态。这两个发现可能解释了为什么用弗氏完全佐剂预处理会抑制在弗氏完全佐剂中用抗原免疫后原本会出现的4小时和24小时皮肤反应。
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