Chaoul Victoria, Dib Emanuel-Youssef, Bedran Joe, Khoury Chakib, Shmoury Omar, Harb Frédéric, Soueid Jihane
Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.
Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Kalhat P.O. Box 100, Lebanon.
Int J Mol Sci. 2023 Oct 4;24(19):14898. doi: 10.3390/ijms241914898.
Neurological diseases, including neurodegenerative and neurodevelopmental disorders, affect nearly one in six of the world's population. The burden of the resulting deaths and disability is set to rise during the next few decades as a consequence of an aging population. To address this, zebrafish have become increasingly prominent as a model for studying human neurological diseases and exploring potential therapies. Zebrafish offer numerous benefits, such as genetic homology and brain similarities, complementing traditional mammalian models and serving as a valuable tool for genetic screening and drug discovery. In this comprehensive review, we highlight various drug delivery techniques and systems employed for therapeutic interventions of neurological diseases in zebrafish, and evaluate their suitability. We also discuss the challenges encountered during this process and present potential advancements in innovative techniques.
神经疾病，包括神经退行性疾病和神经发育障碍，影响着全球近六分之一的人口。由于人口老龄化，在未来几十年里，由此导致的死亡和残疾负担将会增加。为了解决这一问题，斑马鱼作为研究人类神经疾病和探索潜在治疗方法的模型，其地位日益突出。斑马鱼具有许多优势，比如基因同源性和大脑相似性，可作为传统哺乳动物模型的补充，并成为基因筛查和药物发现的宝贵工具。在这篇全面的综述中，我们重点介绍了用于斑马鱼神经疾病治疗干预的各种药物递送技术和系统，并评估了它们的适用性。我们还讨论了在此过程中遇到的挑战，并介绍了创新技术的潜在进展。
