和及其 - 葡萄糖苷酶抑制活性的糖苷成分。
Glycoside constituents of and their -glucosidase inhibitory activity.
机构信息
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
出版信息
Nat Prod Res. 2024 Feb-Mar;38(5):759-767. doi: 10.1080/14786419.2023.2196724. Epub 2023 Apr 2.
Four new glycosides, named amplexicosides A-D (-), and five known compounds: benzyl 2-[-D-glucopyranosyl-(1→6)--D-glucopyranosyloxy]-benzoate (), benzyl 2-neohesperidosyloxy-6-hydroxybenzoate (), chrysandroside A (), chrysandroside B () and camelliquercetiside C () were isolated from the branches and leaves of (Pit.) Cohen-Stuart. Their structures were elucidated using HR-ESI-MS and 1D- and 2D-NMR spectra and compared to reported NMR data. All of the isolated compounds were screened in an -glucosidase assay. Compounds , , and significantly inhibited -glucosidase with respective IC values of 254.9 ± 4.2, 304.8 ± 11.9 and 228.1 ± 16.4 μM.
从 （Pit.）Cohen-Stuart 的枝叶中分离得到了四个新的糖苷，分别命名为amplexicosides A-D (-)，以及五个已知化合物：苄基 2-[-D-吡喃葡萄糖基-(1→6)--D-吡喃葡萄糖氧基]-苯甲酸酯 ()、苄基 2-新橙皮糖苷氧基-6-羟基苯甲酸酯 ()、chrysandroside A ()、chrysandroside B () 和 camelliquercetiside C ()。采用高分辨电喷雾质谱和 1D-和 2D-NMR 谱并与报道的 NMR 数据进行比较，阐明了它们的结构。对所有分离得到的化合物进行了 -葡萄糖苷酶抑制活性筛选。化合物 、 、 对 -葡萄糖苷酶具有显著的抑制作用，IC 值分别为 254.9±4.2、304.8±11.9 和 228.1±16.4 μM。
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