Goon Peter, Sauzet Odile, Schuermann Matthias, Oppel Felix, Shao SenYao, Scholtz Lars-Uwe, Sudhoff Holger, Goerner Martin
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, and Departments of Dermatology & Otolaryngology, National University Health System, Singapore, Singapore.
Bielefeld School of Public Health and Department of Business Administration and Economics, University of Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Germany.
NPJ Vaccines. 2023 Apr 1;8(1):49. doi: 10.1038/s41541-023-00644-8.
Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease. Databases were accessed Nov and Dec 2021 [PubMed, Cochrane, Embase and Web of Science]. Main outcome measured was: Mean paired differences in the number of surgeries or recurrences per month. Analyses was performed using: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.) Our results found n = 38 patients, suitable for syntheses with one previous meta-analyses (4 published, 2 unpublished studies) n = 63, total of n = 101 patients. Analyses rendered an overall reduction of 0.123 recurrences or surgeries per month (95% confidence interval [0.064, 0.183]). Our meta-analyses concludes that HPV vaccine is a beneficial adjunct therapy alongside surgery.
复发性呼吸道乳头状瘤病（RRP）是一种发病率较高的罕见疾病。治疗方法为手术。目前的观点是，预防性HPV疫苗因其作用方式而没有治疗益处。对HPV疫苗与手术联合应用的研究进行了荟萃分析，以测试其对疾病负担的影响。于2021年11月和12月检索了数据库[PubMed、Cochrane、Embase和科学网]。主要测量结果为：每月手术或复发次数的平均配对差异。使用Stata模块Mataan（StataCorp. 2019. Stata统计软件：第16版。德克萨斯州大学站：StataCorp有限责任公司）的随机效应最大似然估计模型进行分析。我们的研究结果发现，有38例患者适合与之前的一项荟萃分析（4项已发表、2项未发表的研究）进行综合分析，共63例，总计101例患者。分析结果显示，每月复发或手术次数总体减少0.123次（95%置信区间[0.064, 0.183]）。我们的荟萃分析得出结论，HPV疫苗是手术辅助治疗的有益手段。
