Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Curr Pharm Des. 2023;29(12):928-939. doi: 10.2174/1381612829666230330163645.
Cognitive dysfunction, such as dementia, is the most common neurological disorder that affects memory, perception, learning, and problem-solving. Emerging evidence suggests that nutritional factors may prevent or accelerate the incidence of neurodegenerative diseases.
This systematic review was designed to evaluate the association between pomegranate treatment and cognitive function.
PubMed, Embase, Google Scholar, and Scopus databases were searched to extract original animal and human studies published until July 2021 without date restrictions. Firstly, 215 studies were retrieved via the search strategy. Irrelevant and duplicated studies were screened out, and critical analysis was used to obtain data. The articles' quality and bias risks were assessed by OHAT and Cochrane Collaboration's quality assessment tools.
Finally, 24 articles (20 animal and 4 randomized controlled trial studies) were included in this review. All included animal and human studies indicated that pomegranate treatment was positively associated with improving specific domains of cognitive function.
Our findings demonstrated that pomegranate treatment could improve cognitive function. Therefore, including pomegranate intake during daily life may lower the risk of cognitive impairment at the population level.
认知功能障碍，如痴呆，是最常见的影响记忆、感知、学习和解决问题的神经退行性疾病。新出现的证据表明，营养因素可能预防或加速神经退行性疾病的发生。
本系统评价旨在评估石榴治疗与认知功能之间的关系。
检索 PubMed、Embase、Google Scholar 和 Scopus 数据库，以提取截至 2021 年 7 月发表的原始动物和人类研究，无日期限制。首先，通过搜索策略检索到 215 项研究。筛选出不相关和重复的研究，并使用关键分析获取数据。使用 OHAT 和 Cochrane 协作组的质量评估工具评估文章的质量和偏倚风险。
最终，本综述纳入了 24 篇文章（20 篇动物研究和 4 篇随机对照试验研究）。所有纳入的动物和人类研究均表明，石榴治疗与改善特定认知功能领域呈正相关。
我们的研究结果表明，石榴治疗可以改善认知功能。因此，在日常生活中摄入石榴可能会降低人群认知障碍的风险。
