Department of Health Management Branch, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Pathology, Ruijin Hospital and College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Public Health. 2023 Mar 15;11:1145669. doi: 10.3389/fpubh.2023.1145669. eCollection 2023.
Recent studies have shown that the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reduced under alkaline conditions. The purpose of this study is to assess the effect of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance among COVID-19 patients.
COVID-19 patients were recruited and randomly divided into two group, i.e., the experimental group and the control group. The experimental group received regular care plus nasal irrigation and oral rinse with 5% sodium bicarbonate solution, while the control group only received regular care. Nasopharyngeal and oropharyngeal swab samples were collected daily for reverse transcription-polymerase chain reaction (RT-PCR) assays. The negative conversion time and hospitalization time of the patients were recorded, and the results were statistically analyzed.
A total of 55 COVID-19 patients with mild or moderate symptoms were included in our study. There was no significant difference in gender, age and health status between the two groups. The average negative conversion time was 1.63 days after treatment with sodium bicarbonate, and the average hospitalization time of the control group and the experimental group were 12.53 and 7.7 days, respectively.
Nasal irrigation and oral rinse with 5% sodium bicarbonate solution is effective in virus clearance for COVID-19 patients.
最近的研究表明，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）在碱性条件下的传染性降低。本研究旨在评估 COVID-19 患者用碳酸氢钠溶液进行鼻腔冲洗和口腔冲洗对清除病毒的效果。
招募 COVID-19 患者并将其随机分为两组，即实验组和对照组。实验组接受常规护理加 5%碳酸氢钠溶液鼻腔冲洗和口腔冲洗，而对照组仅接受常规护理。每天采集鼻咽和口咽拭子样本进行逆转录-聚合酶链反应（RT-PCR）检测。记录患者的阴性转换时间和住院时间，并进行统计学分析。
本研究共纳入 55 例有轻度或中度症状的 COVID-19 患者。两组在性别、年龄和健康状况方面无显著差异。用碳酸氢钠治疗后的平均阴性转换时间为 1.63 天，对照组和实验组的平均住院时间分别为 12.53 天和 7.7 天。
5%碳酸氢钠溶液鼻腔冲洗和口腔冲洗对 COVID-19 患者清除病毒有效。
