Wang Xueqin, Xing Yan, Wang Yongyong, Du Zhaoxia, Zhang Chang, Gao Jing
Department of Reproductive Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.
Department of Reproductive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Exp Ther Med. 2023 Mar 10;25(4):179. doi: 10.3892/etm.2023.11878. eCollection 2023 Apr.
Numerous studies have reported single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) associated with unexplained recurrent spontaneous abortion (URSA). The present study aimed to conduct an updated meta-analysis to confirm a pooled effect size of the association between miRNA SNPs and URSA. The relevant literature was searched on PubMed, EMBASE, Web of Science and Cochrane Library before July 2022 to identify case-control studies. The pooled odds ratio and confidence intervals at 95% of the eligible studies were extracted and evaluated under five genetic models. A total of 18 studies involving 3,850 cases and 4,312 controls were included. miR499a rs3746444 A>G, miR-149 rs2292832 T>C, miR-125a rs41275794 G>A and miR-10a rs3809783 A>T may enhance the risk of recurrent spontaneous abortion (RSA) under various genetic models. Although no separate association was found between the miR-125a rs12976445 C>T and miR-27a rs895819 A>G polymorphisms and RSA, statistical significance was found in certain ethnic groups only. The current analysis suggests a high significance of an up-to-date meta-analysis for screening out and preventing URSA among high-risk women by testing miRNA SNPs and RSA susceptibility.
许多研究报告了与不明原因复发性自然流产（URSA）相关的微小RNA（miRNA）中的单核苷酸多态性（SNP）。本研究旨在进行一项更新的荟萃分析，以确认miRNA SNP与URSA之间关联的合并效应大小。于2022年7月之前在PubMed、EMBASE、Web of Science和Cochrane图书馆检索相关文献，以确定病例对照研究。在五种遗传模型下提取并评估符合条件研究的合并比值比和95%置信区间。总共纳入了18项研究，涉及3850例病例和4312例对照。在各种遗传模型下，miR499a rs3746444 A>G、miR-149 rs2292832 T>C、miR-125a rs41275794 G>A和miR-10a rs3809783 A>T可能会增加复发性自然流产（RSA）的风险。虽然未发现miR-125a rs12976445 C>T和miR-27a rs895819 A>G多态性与RSA之间存在单独关联，但仅在某些种族群体中发现了统计学意义。当前分析表明更新的荟萃分析对于通过检测miRNA SNP和RSA易感性在高危女性中筛查和预防URSA具有高度重要性。
