Dickinson R J, Hall A S, Hind A J, Young I R
J Comput Assist Tomogr. 1986 May-Jun;10(3):468-72.
The spin-lattice relaxation time T1 of tissue has been measured as a function of temperature using a magnetic resonance imager. Both in vitro and in vivo tissues have been heated within the imager using radiofrequency power applied to either implanted electrodes or capacitive plates. The temperature distribution was monitored with implanted thermocouples and T1 was found to have a linear dependence with temperature with a slope of 5-10 ms/degrees C. The uncertainty in T1 corresponds to a temperature resolution of 1-2 degrees C, which combined with a spatial resolution of 4-5 mm and scan time of 1 min suggests the method should be valuable for noninvasive temperature mapping in clinical hyperthermia.
利用磁共振成像仪测量了组织的自旋晶格弛豫时间T1随温度的变化。通过施加到植入电极或电容板上的射频功率，在成像仪内对体外和体内组织进行了加热。用植入的热电偶监测温度分布，发现T1与温度呈线性关系，斜率为5-10毫秒/摄氏度。T1的不确定性对应于1-2摄氏度的温度分辨率，再结合4-5毫米的空间分辨率和1分钟的扫描时间，表明该方法对于临床热疗中的无创温度映射应该是有价值的。
