Patel Vaama, Syeda Sarah, Zeiter John, Nassiri Nariman, Kim Chaesik, Truhan Alan, Chapman Christopher, Adam Christopher, Parendo Anthony, Savage Mack, Abrams Gary
Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA.
J Vitreoretin Dis. 2021 Jan 6;5(4):337-344. doi: 10.1177/2474126420975310. eCollection 2021 Jul-Aug.
This study determines whether fluorescein angiography (FA) with a 250-mg dose of fluorescein (half dose) is equal in quality to the standard 500-mg dose of fluorescein (full dose) when using digital ultra-widefield (UWF) technology.
In a randomized, prospective study using a UWF imaging system, FAs performed with half dose were compared with angiograms performed with full dose. Imaging studies were reviewed by 4 reviewers based on 6 characteristics: dye transit, macrovasculature, macula detail, microvasculature, leakage, and overall quality. The scores for macrovasculature, macula detail, microvasculature, and overall quality were converted to a fuzzy rating score to confirm results.
Seventy-nine FAs from 67 patients were reviewed for this study, including 12 patients who had both half-dose and full-dose FAs. Of all the factors studied, only microvasculature received a significantly different score between full dose and half dose that was confirmed by the fuzzy rating scale (3.79 vs 3.53; = .04). Among those eyes that received both full and half dose, there was no significant difference in any of the 6 factors.
In a UWF imaging system, aside from looking at fine microvascular abnormalities, the 250-mg dose of fluorescein provided similar results to a 500-mg dose. The images were not significantly different in overall quality.
本研究旨在确定在使用数字超广角（UWF）技术时，250毫克剂量荧光素（半剂量）的荧光素血管造影（FA）在质量上是否等同于标准的500毫克剂量荧光素（全剂量）。
在一项使用UWF成像系统的随机前瞻性研究中，将半剂量的FA与全剂量的血管造影进行比较。4名观察者基于6项特征对成像研究进行评估：染料通过情况、大血管、黄斑细节、微血管、渗漏及整体质量。将大血管、黄斑细节、微血管和整体质量的评分转换为模糊评分以确认结果。
本研究共评估了67例患者的79次FA，其中12例患者同时接受了半剂量和全剂量FA。在所有研究因素中，只有微血管在全剂量和半剂量之间的评分存在显著差异，模糊评分法确认了这一结果（3.79对3.53；P = 0.04）。在同时接受全剂量和半剂量检查的眼中，6项因素中的任何一项均无显著差异。
在UWF成像系统中，除了观察细微的微血管异常外，250毫克剂量的荧光素与500毫克剂量的荧光素效果相似。图像的整体质量没有显著差异。
