Yannuzzi L A, Rohrer K T, Tindel L J, Sobel R S, Costanza M A, Shields W, Zang E
Ophthalmology. 1986 May;93(5):611-7. doi: 10.1016/s0161-6420(86)33697-2.
This is a report on the results of a national survey designed to study the nature and frequency of moderate and severe complications of intravenous fluorescein angiography. In this survey, 2434 responding ophthalmologists reported on 221,781 fluorescein angiograms performed in the year 1984. Adverse reactions were classified as mild, moderate, severe, and death, depending on the duration of the effect, the necessity for medical intervention, the time required for its resolution, and the final outcome. The frequency rate for a moderate reaction was (1:63), for a severe reaction (1:1900), and for death (1:222,000). A review of previous studies on adverse reactions to the drug, a compilation of suggested methods for the amelioration and prevention of the complications, and a comparison of the responses of the general ophthalmic public to the members of The Macula Society are also reported.
这是一份关于一项全国性调查结果的报告，该调查旨在研究静脉注射荧光素血管造影术的中度和重度并发症的性质及发生频率。在此次调查中，2434名做出回应的眼科医生报告了1984年所进行的221,781例荧光素血管造影术的情况。不良反应根据其影响持续时间、医疗干预的必要性、症状缓解所需时间以及最终结果，分为轻度、中度、重度和死亡。中度反应的发生率为（1:63），重度反应为（1:1900），死亡为（1:222,000）。文中还报告了对该药物不良反应既往研究的回顾、改善和预防并发症的建议方法汇编，以及普通眼科医生与黄斑学会成员的回应比较情况。
