Doroudian Mohammad, Zanganeh Saba, Abbasgholinejad Elham, Donnelly Seamas C
School of Medicine, Trinity College, Trinity Biomedical Sciences Institute, Dublin, Ireland.
Department of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Front Bioeng Biotechnol. 2023 Mar 17;11:1144653. doi: 10.3389/fbioe.2023.1144653. eCollection 2023.
Lung cancer is the major cause of cancer death worldwide. Cancer immunotherapy has been introduced as a promising and effective treatment that can improve the immune system's ability to eliminate cancer cells and help establish immunological memory. Nanoparticles can contribute to the rapidly evolving field of immunotherapy by simultaneously delivering a variety of immunological agents to the target site and tumor microenvironment. Nano drug delivery systems can precisely target biological pathways and be implemented to reprogram or regulate immune responses. Numerous investigations have been conducted to employ different types of nanoparticles for immunotherapy of lung cancer. Nano-based immunotherapy adds a strong tool to the diverse collection of cancer therapies. This review briefly summarizes the remarkable potential opportunities for nanoparticles in lung cancer immunotherapy and its challenges.
肺癌是全球癌症死亡的主要原因。癌症免疫疗法已作为一种有前景且有效的治疗方法被引入，它可以提高免疫系统消除癌细胞的能力，并有助于建立免疫记忆。纳米颗粒可以通过同时将多种免疫制剂递送至靶位点和肿瘤微环境，为迅速发展的免疫疗法领域做出贡献。纳米药物递送系统可以精确靶向生物途径，并用于重新编程或调节免疫反应。已经进行了大量研究，采用不同类型的纳米颗粒进行肺癌免疫治疗。基于纳米的免疫疗法为多样的癌症治疗方法增添了一个强大的工具。本文综述简要总结了纳米颗粒在肺癌免疫治疗中的显著潜在机遇及其面临的挑战。
