Fernández-Aparicio Ángel, Schmidt-RioValle Jacqueline, Perona Javier S, Correa-Rodríguez María, Castellano Jose M, González-Jiménez Emilio
Department of Nursing, Faculty of Health Sciences, University of Granada, Av. Ilustración, 60, 18016 Granada, Spain.
Instituto de la Grasa, Spanish National Research Council (CSIC), Campus University Pablo de Olavide, 41013 Seville, Spain.
J Clin Med. 2019 Aug 23;8(9):1294. doi: 10.3390/jcm8091294.
The high prevalence of obesity is a serious public health problem in today's world. Both obesity and insulin resistance favor the development of metabolic syndrome (MetS), which is associated with a number of pathologies, especially type 2 diabetes mellitus, and cardiovascular diseases. This serious problem highlights the need to search for new natural compounds to be employed in therapeutic and preventive strategies, such as oleanolic acid (OA). This research aimed to systematically review the effects of OA on the main components of MetS as well as oxidative stress in clinical trials and experimental animal studies. Databases searched included PubMed, Medline, Web of Science, Scopus, EMBASE, Cochrane, and CINAHL from 2013 to 2019. Thus, both animal studies ( = 23) and human clinical trials ( = 1) were included in our review to assess the effects of OA formulations on parameters concerning insulin resistance and the MetS components. The methodological quality assessment was performed through using the SYRCLE's Risk of Bias for animal studies and the Jadad scale. According to the studies in our review, OA improves blood pressure levels, hypertriglyceridemia, hyperglycemia, oxidative stress, and insulin resistance. Although there is scientific evidence that OA has beneficial effects in the prevention and treatment of MetS and insulin resistance, more experimental studies and randomized clinical trials are needed to guarantee its effectiveness.
肥胖的高患病率是当今世界一个严重的公共卫生问题。肥胖和胰岛素抵抗都有利于代谢综合征（MetS）的发展，而代谢综合征与多种病理状况相关，尤其是2型糖尿病和心血管疾病。这一严重问题凸显了寻找可用于治疗和预防策略的新天然化合物的必要性，比如齐墩果酸（OA）。本研究旨在系统评价齐墩果酸在临床试验和实验动物研究中对代谢综合征主要成分以及氧化应激的影响。检索的数据库包括2013年至2019年期间的PubMed、Medline、科学网、Scopus、EMBASE、Cochrane和CINAHL。因此，我们的综述纳入了动物研究（n = 23）和人体临床试验（n = 1），以评估齐墩果酸制剂对胰岛素抵抗和代谢综合征各成分相关参数的影响。方法学质量评估通过使用SYRCLE动物研究偏倚风险评估工具和雅达量表进行。根据我们综述中的研究，齐墩果酸可改善血压水平、高甘油三酯血症、高血糖、氧化应激和胰岛素抵抗。尽管有科学证据表明齐墩果酸在预防和治疗代谢综合征及胰岛素抵抗方面具有有益作用，但仍需要更多的实验研究和随机临床试验来确保其有效性。
