Magos-Guerrero Gil Alfonso, Santiago-Mejía Jacinto, Carrasco Omar F
Department of Pharmacology, School of Medicine, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
J Intercult Ethnopharmacol. 2017 Jul 12;6(3):274-279. doi: 10.5455/jice.20170706061922. eCollection 2017 Jul-Sep.
L., (L.) ., . and (Hook. & Grev.) Spring., have been used in Mexican traditional medicine to treat hypertension. The objective of this study was to further characterize the cardiovascular effects of the methanol extracts of such plants.
The medicinal plants were collected and taxonomically identified; the methanol extract of each explored plant were administrated to conscious and unconscious male Wistar rats with and without glucose-induced hypertension. The blood pressure (BP) and heart rate (HR) were evaluated before and after the extract administration. Vascular reactivity experiments were conducted in rat aortic rings obtained from rats with and without sugar-induced hypertension, a model widely used to study such effects with cardiovascular agents.
After oral administration in normotensive conscious rats all tested extracts decreased the HR, such effect was only observed in hypertensive conscious rats after the administration of ; only and decreased the BP after oral administration. All extracts administrated by intravenous injection diminished the mean arterial pressure. Dose-response curves to cumulative concentrations of all the extracts promote vascular relaxation in precontracted aortas from rats with and without sugar-induced hypertension.
The present study indicated that is worthy of further investigation as a potential phytotherapeutic agent for treating hypertension.
L.、(L.) .、. 和 (Hook. & Grev.) Spring. 已被用于墨西哥传统医学治疗高血压。本研究的目的是进一步表征这些植物甲醇提取物的心血管效应。
采集药用植物并进行分类鉴定；将每种受试植物的甲醇提取物给予清醒和麻醉的雄性Wistar大鼠，有无葡萄糖诱导的高血压。在提取物给药前后评估血压（BP）和心率（HR）。在从有和没有糖诱导高血压的大鼠获得的大鼠主动脉环中进行血管反应性实验，这是一种广泛用于研究心血管药物此类效应的模型。
在正常血压清醒大鼠口服给药后，所有受试提取物均降低了心率，这种效应仅在给予 后在高血压清醒大鼠中观察到；口服给药后只有 和 降低了血压。所有通过静脉注射给药的提取物均降低了平均动脉压。对所有提取物累积浓度的剂量反应曲线促进了来自有和没有糖诱导高血压大鼠的预收缩主动脉的血管舒张。
本研究表明，作为一种潜在的治疗高血压的植物治疗剂，值得进一步研究。
