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鼠伤寒沙门氏菌中N-乙酰谷氨酸合成的调控

Regulation of N-acetylglutamate synthesis in Salmonella typhimurium.

作者信息

Abdelal A T, Nainan O V

出版信息

J Bacteriol. 1979 Feb;137(2):1040-2. doi: 10.1128/jb.137.2.1040-1042.1979.

DOI:10.1128/jb.137.2.1040-1042.1979
PMID:370091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218396/
Abstract

N-Acetylglutamate synthase was purified to homogeneity from Salmonella typhimurium. The enzyme is subject to repression and feedback inhibition by arginine. Inhibition studies indicated that arginine exerts its effect primarily by reducing the affinity of the enzyme for glutamate.

摘要

从鼠伤寒沙门氏菌中纯化出了N-乙酰谷氨酸合酶，且该酶已达到同质状态。该酶受到精氨酸的阻遏和反馈抑制。抑制研究表明，精氨酸主要通过降低该酶对谷氨酸的亲和力来发挥其作用。

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本文引用的文献

1
Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
J Biol Chem. 1956 Jan;218(1):97-106.
2
Enzymatic synthesis of acetylglutamate by mammalian liver preparations and its stimulation by arginine.哺乳动物肝脏制剂对乙酰谷氨酸的酶促合成及其受精氨酸的刺激作用。
Biochem Biophys Res Commun. 1971 Sep;44(5):1117-24. doi: 10.1016/s0006-291x(71)80201-2.
3
N-acetylglutamate synthetase of Pseudomonas aeruginosa. An assay in vitro and feedback inhibition by arginine.铜绿假单胞菌的N-乙酰谷氨酸合成酶。体外测定及精氨酸的反馈抑制作用
Eur J Biochem. 1972 Dec 4;31(2):290-5. doi: 10.1111/j.1432-1033.1972.tb02531.x.
4
N-Acetylglutamate synthase of Escherichia coli regulation of synthesis and activity by arginine.大肠杆菌的N-乙酰谷氨酸合酶：精氨酸对其合成与活性的调节
J Biol Chem. 1975 Mar 10;250(5):1690-3.
5
Arginine auxotrophic phenotype of mutation in pyrA of Salmonella typhimurium: role of N-acetylornithine in the maturation of mutant carbamylphosphate synthetase.鼠伤寒沙门氏菌pyrA基因突变的精氨酸营养缺陷型表型：N-乙酰鸟氨酸在突变型氨甲酰磷酸合成酶成熟中的作用。
J Bacteriol. 1978 May;134(2):528-36. doi: 10.1128/jb.134.2.528-536.1978.
6
Isolation and partial characterization of an argR mutant of Salmonella typhimurium.鼠伤寒沙门氏菌argR突变体的分离与部分特性分析。
J Bacteriol. 1976 Nov;128(2):528-35. doi: 10.1128/jb.128.2.528-535.1976.
7
N-Acetylglutamate synthetase from rat-liver mitochondria. Partial purification and catalytic properties.大鼠肝脏线粒体中的N-乙酰谷氨酸合成酶。部分纯化及催化特性
Eur J Biochem. 1978 Mar;84(1):285-91. doi: 10.1111/j.1432-1033.1978.tb12167.x.
8
N-acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties.大肠杆菌的N-乙酰谷氨酸合酶：纯化、特性及分子性质
J Biol Chem. 1977 May 25;252(10):3295-303.