鼠伤寒沙门氏菌argR突变体的分离与部分特性分析。
Isolation and partial characterization of an argR mutant of Salmonella typhimurium.
作者信息
Kelln R A, O'Donovan G A
出版信息
J Bacteriol. 1976 Nov;128(2):528-35. doi: 10.1128/jb.128.2.528-535.1976.
Abstract
An arginine regulatory mutant (i.e., mutated in the argR gene) has been isolated from a strain of Salmonella typhimurium LT2. The argR mutant was found to excrete arginine into the growth medium with glycerol but not glucose as carbon source. Constitutive synthesis of arginine biosynthetic enzymes was observed. Whereas previous results (A. T. Abd-E1-A1 and J. L. Ingraham, Abstr. Annu. Meet. Am. Soc. Microbiol. 1975, K169, p. 175) have shown constitutive synthesis of carbamyl phosphate synthetase in the argR mutant, the regulation of the synthesis of the last five enzymes of the pyrimidine pathway was unaffected. However, in pyrH mutants, known to exhibit derepressed synthesis of the pyrimidine enzymes, a 10-fold derepression of ornithine transcarbamylase was observed.
摘要
从鼠伤寒沙门氏菌LT2菌株中分离出一种精氨酸调节突变体（即argR基因发生突变）。发现该argR突变体在以甘油而非葡萄糖作为碳源的生长培养基中向培养基中分泌精氨酸。观察到精氨酸生物合成酶的组成型合成。尽管先前的结果（A. T. Abd-E1-A1和J. L. Ingraham，《美国微生物学会年会摘要》，1975年，K169，第175页）表明argR突变体中氨甲酰磷酸合成酶存在组成型合成，但嘧啶途径最后五种酶的合成调节未受影响。然而，在已知表现出嘧啶酶去阻遏合成的pyrH突变体中，观察到鸟氨酸转氨甲酰酶有10倍的去阻遏。
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