通过给母鼠接种疫苗来保护幼鼠免受空肠弯曲菌的定植。
The protection of infant mice from colonization with Campylobacter jejuni by vaccination of the dams.
作者信息
Dolby J M, Newell D G
出版信息
J Hyg (Lond). 1986 Apr;96(2):143-51. doi: 10.1017/s0022172400065918.
Abstract
Intraperitoneal vaccination of female mice, before mating, with a whole cell, heat-killed (62 degrees C) vaccine of Campylobacter jejuni allowed the mother to confer immunity to her young, challenged orally 4-6 days after birth with the homologous strain. There was no protection against a strain of another serotype. Heating the vaccine to 100 degrees C destroyed its protective properties. A vaccine prepared from an aflagellate variant of the original strain was as protective as the original vaccine against challenge with the flagellated strain. Anti-flagellar serum antibody titres of the dams did not correlate with protection of their young.
摘要
在交配前，用空肠弯曲菌全细胞热灭活（62摄氏度）疫苗对雌性小鼠进行腹腔接种，可使母鼠将免疫力传递给其幼崽，幼崽在出生后4 - 6天经口感染同源菌株。对另一血清型菌株没有保护作用。将疫苗加热到100摄氏度会破坏其保护特性。用原始菌株的无鞭毛变体制备的疫苗，在抵抗有鞭毛菌株攻击方面与原始疫苗具有同样的保护作用。母鼠的抗鞭毛血清抗体滴度与其幼崽的保护情况无关。
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