Martinez-Quinones Patricia, Bass Gary Alan
Division of Traumatology, Surgical Critical Care, and Emergency Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Center for Peri-Operative Outcomes Research and Transformation (C-PORT), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Surg Infect (Larchmt). 2023 Apr;24(3):232-237. doi: 10.1089/sur.2022.421.
Previously considered inert, the greater omentum is now thought to play a central role in intra-peritoneal immune defense. The intestinal microbiome has recently become a target for potential therapeutic interventions. A narrative review of the immune functions of the omentum was generated using the Scale for the Assessment of Narrative Review Articles (SANRA) guideline. Articles were selected from domains including surgical history, immunology, microbiology, and abdominal sepsis. Evidence suggests the intestinal microbiome may be responsible for some maladaptive physiologic responses in disease states, particularly intra-peritoneal sepsis. Elaborate crosstalk exists between the gut microbiome and the omentum, given its innate and adaptive immune capabilities. We summarize current knowledge, provide examples of how normal and abnormal microbiomes interface with the omentum, and illustrate their impact on surgical disease and its management.
大网膜以前被认为是惰性的，现在被认为在腹膜内免疫防御中起核心作用。肠道微生物群最近已成为潜在治疗干预的目标。使用叙事性综述文章评估量表（SANRA）指南对大网膜的免疫功能进行了叙事性综述。文章选自包括手术史、免疫学、微生物学和腹部脓毒症等领域。有证据表明，肠道微生物群可能是疾病状态下某些适应不良生理反应的原因，尤其是腹膜内脓毒症。鉴于大网膜具有先天性和适应性免疫能力，肠道微生物群与大网膜之间存在着复杂的相互作用。我们总结了当前的知识，举例说明了正常和异常微生物群如何与大网膜相互作用，并阐述了它们对外科疾病及其管理的影响。
