Aljeldah Mohammed M
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafar al-Batin 31991, Saudi Arabia.
Antibiotics (Basel). 2022 Aug 9;11(8):1082. doi: 10.3390/antibiotics11081082.
Antimicrobial resistance (AMR) is a challenge to human wellbeing the world over and is one of the more serious public health concerns. AMR has the potential to emerge as a serious healthcare threat if left unchecked, and could put into motion another pandemic. This establishes the need for the establishment of global health solutions around AMR, taking into account microdata from different parts of the world. The positive influences in this regard could be establishing conducive social norms, charting individual and group behavior practices that favor global human health, and lastly, increasing collective awareness around the need for such action. Apart from being an emerging threat in the clinical space, AMR also increases treatment complexity, posing a real challenge to the existing guidelines around the management of antibiotic resistance. The attribute of resistance development has been linked to many genetic elements, some of which have complex transmission pathways between microbes. Beyond this, new mechanisms underlying the development of AMR are being discovered, making this field an important aspect of medical microbiology. Apart from the genetic aspects of AMR, other practices, including misdiagnosis, exposure to broad-spectrum antibiotics, and lack of rapid diagnosis, add to the creation of resistance. However, upgrades and innovations in DNA sequencing technologies with bioinformatics have revolutionized the diagnostic industry, aiding the real-time detection of causes of AMR and its elements, which are important to delineating control and prevention approaches to fight the threat.
抗微生物药物耐药性（AMR）是全球人类健康面临的一项挑战，也是较为严重的公共卫生问题之一。如果不加以控制，AMR有可能成为严重的医疗威胁，并可能引发另一场大流行。这就需要围绕AMR建立全球卫生解决方案，同时考虑来自世界不同地区的微观数据。在这方面的积极影响可能包括建立有利的社会规范、规划有利于全球人类健康的个人和群体行为模式，以及最后提高围绕此类行动必要性的集体意识。除了在临床领域构成新出现的威胁外，AMR还增加了治疗复杂性，对现有的抗生素耐药性管理指南构成了真正挑战。耐药性发展的特性与许多遗传因素有关，其中一些在微生物之间具有复杂的传播途径。除此之外，正在发现AMR发展背后的新机制，使该领域成为医学微生物学的一个重要方面。除了AMR的遗传方面，其他做法，包括误诊、接触广谱抗生素和缺乏快速诊断，也加剧了耐药性的产生。然而，DNA测序技术与生物信息学的升级和创新彻底改变了诊断行业，有助于实时检测AMR的成因及其要素，这对于确定应对该威胁的控制和预防方法至关重要。
