Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Nat Neurosci. 2023 May;26(5):798-809. doi: 10.1038/s41593-023-01296-6. Epub 2023 Apr 3.
Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how hippocampal neurons track changes in cue-outcome associations remains unclear. Using two-photon calcium imaging, we tracked the same dCA1 and vCA1 neurons across days to determine how responses evolve across phases of odor-outcome learning. Initially, odors elicited robust responses in dCA1, whereas, in vCA1, odor responses primarily emerged after learning and embedded information about the paired outcome. Population activity in both regions rapidly reorganized with learning and then stabilized, storing learned odor representations for days, even after extinction or pairing with a different outcome. Additionally, we found stable, robust signals across CA1 when mice anticipated outcomes under behavioral control but not when mice anticipated an inescapable aversive outcome. These results show how the hippocampus encodes, stores and updates learned associations and illuminates the unique contributions of dorsal and ventral hippocampus.
动物将线索与结果联系起来，并在呈现新信息时更新这些联系。这需要海马体，但海马体神经元如何跟踪线索-结果关联的变化尚不清楚。使用双光子钙成像，我们在几天内跟踪相同的 dCA1 和 vCA1 神经元，以确定在气味-结果学习的各个阶段，反应如何演变。最初，气味在 dCA1 中引起强烈的反应，而在 vCA1 中，气味反应主要在学习后出现，并嵌入了配对结果的信息。两个区域的群体活动随着学习迅速重新组织，然后稳定下来，将学习的气味表示存储数天，即使在消退或与不同的结果配对后也是如此。此外，当老鼠在行为控制下预期结果时，我们在 CA1 中发现了稳定、强烈的信号，但当老鼠预期不可避免的厌恶结果时，没有发现这种信号。这些结果表明了海马体如何对学习关联进行编码、存储和更新，并揭示了背侧和腹侧海马体的独特贡献。
