Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Int J Obes (Lond). 2023 Jul;47(7):583-589. doi: 10.1038/s41366-023-01302-8. Epub 2023 Apr 3.
Infant weight patterns predict subsequent weight outcomes. Rapid infant weight gain, defined as a >0.67 increase in weight-for-age z-score (WAZ) between two time points in infancy, increases obesity risk. Higher oxidative stress, an imbalance between antioxidants and reactive oxygen species, has been associated with low birthweight and paradoxically also with later obesity. We hypothesized that prenatal oxidative stress may also be associated with rapid infant weight gain, an early weight pattern associated with future obesity.
Within the NYU Children's Health and Environment Study prospective pregnancy cohort, we analyzed associations between prenatal lipid, protein, and DNA urinary oxidative stress biomarkers and infant weight data. Primary outcome was rapid infant weight gain (>0.67 increase in WAZ) between birth and later infancy at the 8 or 12 month visit. Secondary outcomes included: very rapid weight gain (>1.34 increase in WAZ), low (<2500 g) or high (≥4000 g) birthweight, and low (< -1 WAZ) or high (>1 WAZ) 12 month weight.
Pregnant participants consented to the postnatal study (n = 541); 425 participants had weight data both at birth and in later infancy. In an adjusted binary model, prenatal 8-iso-PGF2α, a lipid oxidative stress biomarker, was associated with rapid infant weight gain (aOR 1.44; 95% CI: 1.16, 1.78, p = 0.001). In a multinomial model using ≤0.67 change in WAZ as a reference group, 8-iso-PGF2α was associated with rapid infant weight gain (defined as >0.67 but ≤1.34 WAZ; aOR 1.57, 95% CI: 1.19, 2.05, p = 0.001) and very rapid infant weight gain (defined as >1.34 WAZ; aOR 1.33; 95% CI: 1.02, 1.72, p < 0.05) Secondary analyses detected associations between 8-iso-PGF2α and low birthweight outcomes.
We found an association between 8-iso-PGF2α, a lipid prenatal oxidative stress biomarker, and rapid infant weight gain, expanding our understanding of the developmental origins of obesity and cardiometabolic disease.
婴儿体重模式可预测后续的体重结果。快速婴儿体重增长，定义为在婴儿期的两个时间点之间体重与年龄 z 评分（WAZ）增加>0.67，会增加肥胖风险。较高的氧化应激，即抗氧化剂和活性氧之间的不平衡，与低出生体重有关，而且与后来的肥胖有关。我们假设产前氧化应激也可能与快速婴儿体重增长有关，这种早期的体重模式与未来肥胖有关。
在纽约大学儿童健康与环境研究前瞻性妊娠队列中，我们分析了产前脂质、蛋白质和 DNA 尿液氧化应激生物标志物与婴儿体重数据之间的关联。主要结果是出生后和 8 或 12 个月随访时 WAZ 增加>0.67 的快速婴儿体重增长。次要结果包括：体重增长非常快（WAZ 增加>1.34）、低体重（<2500g）或高体重（≥4000g）、低体重（< -1 WAZ）或高体重（>1 WAZ）12 个月体重。
怀孕参与者同意参加产后研究（n=541）；425 名参与者在出生时和婴儿期后期都有体重数据。在调整后的二项模型中，脂质氧化应激生物标志物 8-异前列腺素 F2α（8-iso-PGF2α）与快速婴儿体重增长有关（优势比 1.44；95%可信区间：1.16，1.78，p=0.001）。在以 WAZ 变化≤0.67 为参考组的多项模型中，8-iso-PGF2α与快速婴儿体重增长（定义为>0.67 但≤1.34 WAZ；优势比 1.57，95%可信区间：1.19，2.05，p=0.001）和非常快速婴儿体重增长（定义为>1.34 WAZ；优势比 1.33；95%可信区间：1.02，1.72，p<0.05）有关。二次分析检测到 8-iso-PGF2α 与低出生体重结局之间的关联。
我们发现 8-iso-PGF2α（一种脂质产前氧化应激生物标志物）与快速婴儿体重增长之间存在关联，这扩展了我们对肥胖和心血管代谢疾病发育起源的理解。
