脂质循环并非完全无用。 - Suppr

Lipid cycling isn't all futile.

作者信息

Sharma Anand Kumar, Wolfrum Christian

机构信息

Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.

出版信息

Nat Metab. 2023 Apr;5(4):540-541. doi: 10.1038/s42255-023-00779-x.

DOI:10.1038/s42255-023-00779-x

PMID:37012497

Abstract

摘要

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Lipid cycling isn't all futile.

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Effect of tumor burden on futile glucose and lipid cycling in tumor-bearing animals.

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Aging Cell. 2024 Dec;23(12):e14321. doi: 10.1111/acel.14321. Epub 2024 Aug 23.

Futile lipid cycling: from biochemistry to physiology.

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本文引用的文献

Triglyceride cycling enables modification of stored fatty acids.

Nat Metab. 2023 Apr;5(4):699-709. doi: 10.1038/s42255-023-00769-z. Epub 2023 Apr 3.

Higher than predicted resting energy expenditure and lower physical activity in healthy underweight Chinese adults.

Cell Metab. 2022 Oct 4;34(10):1413-1415. doi: 10.1016/j.cmet.2022.05.012. Epub 2022 Jul 14.

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.

Mol Metab. 2022 Jul;61:101499. doi: 10.1016/j.molmet.2022.101499. Epub 2022 Apr 22.

ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity.

Rev Endocr Metab Disord. 2022 Feb;23(1):121-131. doi: 10.1007/s11154-021-09690-w. Epub 2021 Nov 6.

Adipose lipid turnover and long-term changes in body weight.

Nat Med. 2019 Sep;25(9):1385-1389. doi: 10.1038/s41591-019-0565-5. Epub 2019 Sep 9.

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Cell Metab. 2017 Aug 1;26(2):407-418.e3. doi: 10.1016/j.cmet.2017.07.012.

The functional significance of individual variation in basal metabolic rate.

Physiol Biochem Zool. 2004 Nov-Dec;77(6):900-15. doi: 10.1086/427059.

The production and release of glycerol by adipose tissue incubated in vitro.

J Biol Chem. 1962 Nov;237:3354-8.

Glyceroneogenesis and the triglyceride/fatty acid cycle.

J Biol Chem. 2003 Aug 15;278(33):30413-6. doi: 10.1074/jbc.R300017200. Epub 2003 Jun 4.

A futile metabolic cycle activated in adipocytes by antidiabetic agents.

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相似文献

Lipid cycling isn't all futile.

Nat Metab. 2023 Apr;5(4):540-541. doi: 10.1038/s42255-023-00779-x.

Effect of tumor burden on futile glucose and lipid cycling in tumor-bearing animals.

J Surg Res. 1993 Jul;55(1):68-73. doi: 10.1006/jsre.1993.1110.

Fluoroquinolone-resistant pneumococci: maybe resistance isn't futile?

Clin Infect Dis. 2005 Jan 15;40(2):236-8. doi: 10.1086/426822. Epub 2004 Dec 21.

Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?

Am J Clin Nutr. 2004 Jan;79(1):40-6. doi: 10.1093/ajcn/79.1.40.

Telling isn't teaching--and listening isn't learning.

Nurs Times. 1969 Jan 23;65(4):116-7.

What QA is and isn't. What TQM is and isn't.

QRC Advis. 1991 Jun;7(8):1-6.

If it isn't documented, it isn't done.

J Am Health Care Assoc. 1979 Jan;5(1):71-4.

Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid.

PLoS One. 2018 Nov 29;13(11):e0208048. doi: 10.1371/journal.pone.0208048. eCollection 2018.

Aortic clamping and stroke: Because two isn't worse doesn't mean one isn't better.

J Thorac Cardiovasc Surg. 2018 Oct;156(4):1458-1459. doi: 10.1016/j.jtcvs.2018.03.114. Epub 2018 Apr 4.

Afferent isn't efferent, and language isn't logic, either.

Behav Brain Sci. 2003 Jun;26(3):286-287. doi: 10.1017/S0140525X0325007X.

引用本文的文献

Selective remodelling of the adipose niche in obesity and weight loss.

Nature. 2025 Jul 9. doi: 10.1038/s41586-025-09233-2.

Molecular mechanisms of UCP1-independent thermogenesis: the role of futile cycles in energy dissipation.

J Physiol Biochem. 2025 May 17. doi: 10.1007/s13105-025-01090-x.

Regulating triacylglycerol cycling for high-efficiency production of polyunsaturated fatty acids and derivatives.

Nat Commun. 2025 May 8;16(1):4262. doi: 10.1038/s41467-025-59599-0.

Cancer cachexia: multilevel metabolic dysfunction.

Nat Metab. 2024 Dec;6(12):2222-2245. doi: 10.1038/s42255-024-01167-9. Epub 2024 Nov 22.

Chronic β3-AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice.

Aging Cell. 2024 Dec;23(12):e14321. doi: 10.1111/acel.14321. Epub 2024 Aug 23.

Futile lipid cycling: from biochemistry to physiology.

Nat Metab. 2024 May;6(5):808-824. doi: 10.1038/s42255-024-01003-0. Epub 2024 Mar 8.

Lipid droplets and cellular lipid flux.

Nat Cell Biol. 2024 Mar;26(3):331-345. doi: 10.1038/s41556-024-01364-4. Epub 2024 Mar 7.

本文引用的文献

Triglyceride cycling enables modification of stored fatty acids.

Nat Metab. 2023 Apr;5(4):699-709. doi: 10.1038/s42255-023-00769-z. Epub 2023 Apr 3.

Higher than predicted resting energy expenditure and lower physical activity in healthy underweight Chinese adults.

Cell Metab. 2022 Oct 4;34(10):1413-1415. doi: 10.1016/j.cmet.2022.05.012. Epub 2022 Jul 14.

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.

Mol Metab. 2022 Jul;61:101499. doi: 10.1016/j.molmet.2022.101499. Epub 2022 Apr 22.

ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity.

Rev Endocr Metab Disord. 2022 Feb;23(1):121-131. doi: 10.1007/s11154-021-09690-w. Epub 2021 Nov 6.

Adipose lipid turnover and long-term changes in body weight.

Nat Med. 2019 Sep;25(9):1385-1389. doi: 10.1038/s41591-019-0565-5. Epub 2019 Sep 9.

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Cell Metab. 2017 Aug 1;26(2):407-418.e3. doi: 10.1016/j.cmet.2017.07.012.

The functional significance of individual variation in basal metabolic rate.

Physiol Biochem Zool. 2004 Nov-Dec;77(6):900-15. doi: 10.1086/427059.

The production and release of glycerol by adipose tissue incubated in vitro.

J Biol Chem. 1962 Nov;237:3354-8.

Glyceroneogenesis and the triglyceride/fatty acid cycle.

J Biol Chem. 2003 Aug 15;278(33):30413-6. doi: 10.1074/jbc.R300017200. Epub 2003 Jun 4.

A futile metabolic cycle activated in adipocytes by antidiabetic agents.

Nat Med. 2002 Oct;8(10):1122-8. doi: 10.1038/nm780. Epub 2002 Sep 23.

Lipid cycling isn't all futile.

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