Mathiowetz Alyssa J, Olzmann James A
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Nat Cell Biol. 2024 Mar;26(3):331-345. doi: 10.1038/s41556-024-01364-4. Epub 2024 Mar 7.
Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid droplets in regulating fatty acid flux in lipotoxicity and cell death.
脂滴是储存中性脂质、满足细胞代谢需求并隔离脂质以防止脂毒性和膜损伤的动态细胞器。在此，我们综述了目前对脂滴生物发生和周转机制、膜接触位点脂质和代谢物转移以及脂滴在调节脂毒性和细胞死亡中脂肪酸通量作用的理解。
