Chisholm M
Postgrad Med J. 1974 Apr;50(582):215-9. doi: 10.1136/pgmj.50.582.215.
The association of iron deficiency anaemia, post-cricoid webs and carcinoma is controversial. The main findings in a recent study which re-examined this problem are presented here. It was shown that the majority of patients with a post-cricoid web have evidence of iron deficiency but that only about 10% of patients with iron deficiency develop post-cricoid webs. Factors which might be important in the pathogenesis of a post-cricoid web have been looked for and a few significant points noted. The main findings were an increased frequency of angular stomatitis and edentia, thyroid disease and thyroid cytoplasmic antibodies in patients with webs compared with patients with iron deficiency anaemia without a web. Follow-up studies in patients with a post-cricoid web or Paterson-Kelly syndrome show an increased frequency of post-cricoid carcinoma ranging from 4 to 16% in different series and the association is even more striking in patients presenting with post-cricoid carcinoma. It is concluded that the available evidence confirms the association between iron deficiency, postcricoid webs and carcinoma but the mechanism of the production of these changes is not yet understood.
缺铁性贫血、环状软骨后蹼与癌之间的关联存在争议。本文介绍了最近一项重新审视该问题的研究的主要发现。结果显示，大多数环状软骨后蹼患者有缺铁证据，但缺铁患者中只有约10%会出现环状软骨后蹼。已寻找了可能在环状软骨后蹼发病机制中起重要作用的因素，并注意到了一些重要要点。主要发现是，与无蹼的缺铁性贫血患者相比，有蹼患者的口角炎和无牙症、甲状腺疾病及甲状腺细胞质抗体的发生率更高。对环状软骨后蹼或帕特森 - 凯利综合征患者的随访研究表明，环状软骨后癌的发生率在不同系列中为4%至16%，且在环状软骨后癌患者中这种关联更为显著。结论是，现有证据证实了缺铁、环状软骨后蹼与癌之间的关联，但这些变化产生的机制尚不清楚。
