Internal Medicine, Cardiovascular Center, Yangjiang People's Hospital, Guangdong, China.
BMC Med Genomics. 2023 Apr 3;16(1):71. doi: 10.1186/s12920-023-01501-2.
Acute myocardial infarction (AMI) is a common cardiovascular disease that can lead to myocardial necrosis and a poor prognosis. Clinical practice requires an accurate and quick diagnosis of AMI due to the inherent limitations of current biomarkers. Therefore, research into novel biomarkers is necessary. We aimed to explore the diagnostic potency of the long non-coding RNA (lncRNA) N1LR and SNHG1 in patients diagnosed with AMI.
We measured lncRNA levels in 148 AMI patients and 50 healthy volunteers with quantitative RT-PCR method. Receiver operating characteristic (ROC) analysis was administered to detect the diagnostic power of selected lncRNAs. Correlation analysis was performed to explore the relationship between N1LR as well as SNHG1 and the conventional myocardial biomarkers (LDH, CK, CKMB and cTnI).
ROC analysis reveals the possibility of N1LR and SNHG1 as biomarkers in AMI diagnosis (AUC of N1LR: 0.873; AUC of SNHG1: 0.890). Correlation analysis revealed that N1LR was negatively correlated with the conventional biomarkers and SNHG1 was positively correlated with the conventional biomarkers.
For the first time, we investigated the potential predictive diagnostic value of N1LR and SNHG1 in AMI diagnosis and substantial outcomes were obtained. Also, they may be capable of reflecting the progress of the disease during clinical practice from the correlation analysis.
急性心肌梗死（AMI）是一种常见的心血管疾病，可导致心肌坏死和预后不良。由于目前生物标志物的固有局限性，临床实践需要准确快速地诊断 AMI。因此，有必要研究新的生物标志物。我们旨在探讨长链非编码 RNA（lncRNA）N1LR 和 SNHG1 在诊断 AMI 患者中的诊断效力。
我们使用定量 RT-PCR 方法测量了 148 例 AMI 患者和 50 名健康志愿者的 lncRNA 水平。进行了接收者操作特征（ROC）分析，以检测所选 lncRNAs 的诊断能力。进行了相关性分析，以探讨 N1LR 和 SNHG1 与常规心肌生物标志物（LDH、CK、CKMB 和 cTnI）之间的关系。
ROC 分析表明 N1LR 和 SNHG1 作为 AMI 诊断生物标志物的可能性（N1LR 的 AUC：0.873；SNHG1 的 AUC：0.890）。相关性分析表明，N1LR 与常规生物标志物呈负相关，SNHG1 与常规生物标志物呈正相关。
我们首次研究了 N1LR 和 SNHG1 在 AMI 诊断中的潜在预测诊断价值，并取得了重要结果。此外，从相关性分析来看，它们在临床上可能能够反映疾病的进展。
