Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand.
Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand.
Lipids Health Dis. 2023 Apr 3;22(1):47. doi: 10.1186/s12944-023-01811-5.
Insulin resistance (IR) is a major pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity to assess IR and NAFLD due to its simplicity and low cost. The aim of the current study was to evaluate the relationship between the TyG index and aminotransferase.
A serial cross-sectional study was conducted among 232,235 Royal Thai Army (RTA) personnel aged 35-60 years from 2017-2021. Elevated aminotransferase was defined as ≥ 40 U/L and ≥ 35 U/L among males and females, respectively. A linear regression analysis between the TyG index and log-transformed aminotransferase was performed. High- and low-TyG index groups were divided according to Youden's index cut point for predicting elevated aminotransferase. Multivariable logistic analysis was also utilized to investigate the association between the TyG index and elevated aminotransferase.
The TyG index revealed a dose‒response relationship with log-transformed aminotransferase in both sexes and all age groups. The TyG index was positively associated with the prevalence of elevated aminotransferases. In comparison with the first TyG quartile (< 8.37), participants in the fourth quartile (> 9.23) had a higher chance for elevated ALT (AOR: 2.81, 95% CI: 2.71-2.90 for males and AOR: 4.01, 95% CI: 3.50-4.60 for females, P < 0.001 for both). In the fourth TyG quartile, the prevalence of elevated ALT was 47.8% and 40.2% in the participants aged 35-44 and male participants, respectively.
A high TyG index is a novel risk factor for elevated aminotransferase among RTA personnel. Those with a high TyG index should be screened for elevated aminotransferase, particularly males aged 35-44 years.
胰岛素抵抗（IR）是非酒精性脂肪性肝病（NAFLD）的主要发病机制。由于其简单性和低成本，甘油三酯-葡萄糖（TyG）指数最近已被广泛用于评估 IR 和 NAFLD。本研究的目的是评估 TyG 指数与氨基转移酶之间的关系。
对 2017-2021 年期间年龄在 35-60 岁的 232235 名泰国皇家陆军（RTA）人员进行了一项连续的横断面研究。氨基转移酶升高定义为男性和女性分别为≥40 U/L 和≥35 U/L。对 TyG 指数与 log 转换氨基转移酶之间进行线性回归分析。根据预测氨基转移酶升高的 Youden 指数切点将高和低 TyG 指数组进行划分。还利用多变量逻辑分析来研究 TyG 指数与氨基转移酶升高之间的关系。
TyG 指数与两性和所有年龄组的 log 转换氨基转移酶呈剂量反应关系。TyG 指数与升高的氨基转移酶患病率呈正相关。与第一 TyG 四分位数（<8.37）相比，第四四分位数（>9.23）的参与者发生 ALT 升高的几率更高（男性的比值比：2.81，95%置信区间：2.71-2.90；女性的比值比：4.01，95%置信区间：3.50-4.60，两者均<0.001）。在第四 TyG 四分位数中，35-44 岁和男性参与者的 ALT 升高的患病率分别为 47.8%和 40.2%。
高 TyG 指数是 RTA 人员氨基转移酶升高的新危险因素。那些 TyG 指数较高的人应进行氨基转移酶升高的筛查，特别是年龄在 35-44 岁的男性。
