Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, NO. 1, Jianshe East Road, 450052, Zhengzhou, Henan Province, China.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, NO. 1, Jianshe East Road, 450052, Zhengzhou, Henan Province, China.
BMC Endocr Disord. 2022 Oct 26;22(1):261. doi: 10.1186/s12902-022-01172-7.
Lipid and glucose metabolism abnormalities are associated with nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index is a recently developed indicator that can identify individuals at risk for NAFLD. However, the applicability of the TyG index for identifying NAFLD in patients with type 2 diabetes mellitus (T2DM) is unclear. The aim of this study was to investigate the ability of the TyG index to identify individuals at risk for NAFLD in the T2DM population.
A total of 2280 participants with T2DM were recruited in this cross-sectional study. The TyG index was calculated, and NAFLD was diagnosed by ultrasonography. Binary logistic regression models were used to evaluate the association of the TyG index, glycemic parameters and lipid parameters with NAFLD.
Logistic regression analysis showed that the TyG index was significantly associated with NAFLD in subjects with T2DM, the odds ratio (OR) were 3.27 (95% confidence interval [CI], 2.03-5.27; P < 0.001) for NAFLD in the highest TyG quartile after adjustment for known confounders. In stratified analysis, an elevated TyG index were more remarkably associated with NAFLD in younger patients (< 65 years; OR, 2.35; 95% CI, 1.83-3.02; P < 0.001), females (OR, 2.69; 95% CI, 1.67-4.32; P < 0.001), patients with BMI < 25 kg/m (OR, 2.80; 95% CI, 2.01-3.91; P < 0.0001), and with lower high-density lipoprotein cholesterol (< 1 mmol/L; OR, 2.76; 95% CI, 1.98-3.83; P < 0.001).
The TyG index is significantly associated with NAFLD and shows superior ability for identify NAFLD risk compared with other lipid and glycemic parameters in T2DM.
脂质和葡萄糖代谢异常与非酒精性脂肪性肝病（NAFLD）有关。甘油三酯-葡萄糖（TyG）指数是一种新开发的指标，可用于识别 NAFLD 风险人群。然而，该指数在 2 型糖尿病（T2DM）患者中识别 NAFLD 的适用性尚不清楚。本研究旨在探讨 TyG 指数在 T2DM 人群中识别 NAFLD 风险人群的能力。
本横断面研究共纳入 2280 名 T2DM 患者。计算 TyG 指数，并通过超声诊断 NAFLD。采用二元逻辑回归模型评估 TyG 指数、血糖参数和血脂参数与 NAFLD 的相关性。
逻辑回归分析显示，TyG 指数与 T2DM 患者的 NAFLD 显著相关，在调整已知混杂因素后，TyG 最高四分位组的比值比（OR）为 3.27（95%置信区间[CI]，2.03-5.27；P<0.001）。分层分析显示，在年龄较小（<65 岁；OR，2.35；95%CI，1.83-3.02；P<0.001）、女性（OR，2.69；95%CI，1.67-4.32；P<0.001）、BMI<25kg/m（OR，2.80；95%CI，2.01-3.91；P<0.0001）和高密度脂蛋白胆固醇较低（<1mmol/L；OR，2.76；95%CI，1.98-3.83；P<0.001）的患者中，TyG 指数与 NAFLD 的相关性更为显著。
TyG 指数与 NAFLD 显著相关，与其他血脂和血糖参数相比，其在 T2DM 中识别 NAFLD 风险的能力更强。
