Zheng H-T, Zhao Q-Y, Ding Y, Ma S-X, Chen W-X, Qiu J-L, Li X-F, -X Sun X, Zhang Y-J, Yuan B, Yan Y-B
Department of Pediatrics, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Eur Rev Med Pharmacol Sci. 2023 Mar;27(6):2671-2678. doi: 10.26355/eurrev_202303_31804.
The aim of this work was to evaluate the relationships among respiratory syncytial virus infection, T cell immune response and intestinal flora. Peer-reviewed papers published in English were collected through extensive searches performed in PubMed, Web of Science, Google Scholar, and China National Knowledge Infrastructure databases. The articles were reviewed to extract relevant information on the immune responses of Th1/Th2 and Treg/Th17 to respiratory syncytial virus infection in the body. RSV (Respiratory syncytial virus, RSV) infection leads to imbalance between Th1/Th2 and Treg/Th17 immune cells, resulting in Th2 or Th17 dominant immune responses, which can generate immune disorder and aggravate clinical symptoms. Intestinal micro-organisms play very important roles in maintaining stable immune environment, stimulating immune system maturation and balancing Th1/Th2 and Treg/Th17 immune systems in children. In our review of various papers from around the world, we speculated that the steady state of intestinal bacteria was disturbed after children got infected with RSV, resulting in intestinal flora disorder. Then, the imbalance between Th1/Th2 and Treg/Th17 immune cells was increased. Both intestinal flora disorder and RSV infection could cause cellular immunity imbalance of Th1/Th2 or Treg/Th17, eventually leading to disease deterioration and even a vicious cycle. Normal intestinal flora can maintain immune system stability, regulate the dynamic balance of Th1/Th2 and Treg/Th17 and prevent or mitigate adverse consequences of RSV infection. Because probiotics can improve intestinal barrier function and regulate immune response, they can effectively be used to treat children with recurrent respiratory tract infections. Using conventional antiviral therapy strategy supplemented with probiotics in the treatment of clinical RSV infection may be better for the body.
这项工作的目的是评估呼吸道合胞病毒感染、T细胞免疫反应和肠道菌群之间的关系。通过在PubMed、科学网、谷歌学术和中国知网数据库中进行广泛检索，收集了以英文发表的经同行评审的论文。对这些文章进行综述，以提取关于体内Th1/Th2和Treg/Th17对呼吸道合胞病毒感染的免疫反应的相关信息。呼吸道合胞病毒（RSV）感染导致Th1/Th2和Treg/Th17免疫细胞之间失衡，产生Th2或Th17主导的免疫反应，这会引发免疫紊乱并加重临床症状。肠道微生物在维持儿童稳定的免疫环境、刺激免疫系统成熟以及平衡Th1/Th2和Treg/Th17免疫系统方面发挥着非常重要的作用。在我们对世界各地各种论文的综述中，我们推测儿童感染RSV后肠道细菌的稳态受到干扰，导致肠道菌群失调。然后，Th1/Th2和Treg/Th17免疫细胞之间的失衡加剧。肠道菌群失调和RSV感染均可导致Th1/Th2或Treg/Th17细胞免疫失衡，最终导致病情恶化甚至恶性循环。正常的肠道菌群可以维持免疫系统的稳定性，调节Th1/Th2和Treg/Th17的动态平衡，并预防或减轻RSV感染的不良后果。由于益生菌可以改善肠道屏障功能并调节免疫反应，它们可有效用于治疗反复呼吸道感染的儿童。在临床RSV感染的治疗中，采用常规抗病毒治疗策略并辅以益生菌可能对身体更好。
