Li Wenzhen, Chen Dajie, Peng Ying, Lu Zuxun, Wang Dongming
Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Obesity (Silver Spring). 2023 May;31(5):1392-1401. doi: 10.1002/oby.23691. Epub 2023 Apr 4.
This study aimed to evaluate the relationship of polycyclic aromatic hydrocarbon (PAH) exposure with metabolic syndrome (MetS) and its components and to explore the potential mechanism.
Participants from the National Health and Nutrition Examination Survey (NHANES 2001-2016) were included.
A total of 6532 adults and 1237 adolescents were included in the present analysis. For adults, the odds ratios (ORs) and 95% CIs for each one-unit increase in the log-transformed level of 1-hydroxynaphthalene (1-OHNa), 2-hydroxynaphthalene (2-OHNa), 3-hydroxyfluorene (3-OHFlu), 2-hydroxyfluorene (2-OHFlu), 1-hydroxyphenanthrene (1-OHPh), 1-hydroxypyrene (1-OHP), 2- and 3-hydroxyphenanthrene (2&3-OHPh), and total urinary PAH metabolites (∑OH-PAHs) with MetS were 1.11 (1.03-1.20), 1.18 (1.07-1.29), 1.10 (1.01-1.12), 1.18 (1.07-1.30), 1.17 (1.03-1.33), 1.09 (1.01-1.22), 1.24 (1.09-1.40), and 1.17 (1.06-1.29), respectively. They were 1.61 (1.21-2.14) for 2-OHNa, 1.27 (1.01-1.60) for 2-OHFlu, 1.53 (1.15-2.03) for 1-OHPh, and 1.61 (1.20-2.15) for ∑OH-PAHs among adolescents. C-reactive protein was not only positively associated with urinary PAH metabolites, but also positively related to MetS, and it mediated 10.23% to 20.21% for urinary PAH metabolites and MetS among adults.
PAH exposure is associated with a higher prevalence of MetS or MetS components among adults and adolescents. Systemic inflammation partly mediated the association among adults.
本研究旨在评估多环芳烃（PAH）暴露与代谢综合征（MetS）及其组分之间的关系，并探索潜在机制。
纳入来自国家健康与营养检查调查（NHANES 2001 - 2016）的参与者。
本分析共纳入6532名成年人和1237名青少年。对于成年人，1 - 羟基萘（1 - OHNa）、2 - 羟基萘（2 - OHNa）、3 - 羟基芴（3 - OHFlu）、2 - 羟基芴（2 - OHFlu）、1 - 羟基菲（1 - OHPh）、1 - 羟基芘（1 - OHP）、2和3 - 羟基菲（2&3 - OHPh）以及总尿PAH代谢物（∑OH - PAHs）的对数转换水平每增加一个单位，与MetS的比值比（ORs）及95%置信区间分别为1.11（1.03 - 1.20）、1.18（1.07 - 1.29）、1.10（1.01 - 1.12）、1.18（1.07 - 1.30）、1.17（1.03 - 1.33）、1.09（1.01 - 1.22）、1.24（1.09 - 1.40）和1.17（1.06 - 1.29）。青少年中，2 - OHNa的OR为1.61（1.21 - 2.14），2 - OHFlu为1.27（1.01 - 1.60），1 - OHPh为1.53（1.15 - 2.03），∑OH - PAHs为1.61（1.20 - 2.15）。C反应蛋白不仅与尿PAH代谢物呈正相关，还与MetS呈正相关，且在成年人中它介导了尿PAH代谢物与MetS之间10.23%至20.21%的关联。
PAH暴露与成年人及青少年中MetS或MetS组分的较高患病率相关。全身炎症在成年人中部分介导了这种关联。
