Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 4300230, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2R3, Canada.
J Environ Sci (China). 2025 Apr;150:412-421. doi: 10.1016/j.jes.2024.01.043. Epub 2024 Feb 14.
The associations of polycyclic aromatic hydrocarbon (PAH) exposure with serum uric acid (SUA) or hyperuricemia have been rarely assessed. We aimed to investigate the relationships between urinary PAH metabolites and SUA or hyperuricemia among US adults and to explore the mediating role of systemic inflammation in the associations. A total of 10,307 US adults were conducted to assess the associations of seven urinary hydroxy‑PAH with SUA and hyperuricemia and evaluate the role of C-reactive protein (CRP), a biomarker of systemic inflammation, in such associations. Results showed that each 1-unit increase in ln-transformed 2-hydroxynaphthalene (2-OHNa), 1-hydroxyphenanthrene (1-OHPh), 2&3-hydroxyphenanthrene (2&3-OHPh) and total hydroxyphenanthrene (ΣOHPh) was associated with a 1.68 (95% confidence interval (CI): 0.19 to 3.17), 2.46 (0.78 to 4.13), 3.34 (1.59 to 5.09), and 2.99 (1.23 to 4.75) µmol/L increase in SUA, and a 8% (odds ratio (OR): 1.08, 1.02 to 1.15), 9% (OR: 1.09, 1.02 to 1.18), 13% (OR: 1.13, 1.05 to 1.22), and 12% (OR: 1.12, 95% CI: 1.03, 1.21) increase in hyperuricemia, respectively. Co-exposure of seven PAHs was positively associated with SUA and hyperuricemia, with 2&3-OHPh showing the highest weight (components weights: 0.83 and 0.78, respectively). The CRP mediated 11.47% and 10.44% of the associations of ΣOHPh and 2&3-OHPh with SUA and mediated 8.60% and 8.62% in associations of ΣOHPh and 2&3-OHPh with hyperuricemia, respectively. In conclusion, internal levels of PAH metabolites were associated with elevated SUA levels and the increased risk of hyperuricemia among US adults, and CRP played a mediating role in the associations.
多环芳烃（PAH）暴露与血清尿酸（SUA）或高尿酸血症之间的关联很少被评估。我们旨在研究美国成年人尿液中多环芳烃代谢物与 SUA 或高尿酸血症之间的关系，并探讨全身炎症在这些关联中的中介作用。共有 10307 名美国成年人参与了这项研究，以评估七种尿液羟基-PAH 与 SUA 和高尿酸血症之间的关联，并评估 C 反应蛋白（CRP），一种全身炎症的生物标志物，在这些关联中的作用。结果表明，ln 转化的 2-羟基萘（2-OHNa）、1-羟基菲（1-OHPh）、2&3-羟基菲（2&3-OHPh）和总羟基菲（ΣOHPh）每增加 1 个单位，SUA 分别增加 1.68（95%置信区间（CI）：0.19 至 3.17）、2.46（0.78 至 4.13）、3.34（1.59 至 5.09）和 2.99（1.23 至 4.75）µmol/L，尿酸水平分别增加 8%（比值比（OR）：1.08，1.02 至 1.15）、9%（OR：1.09，1.02 至 1.18）、13%（OR：1.13，1.05 至 1.22）和 12%（OR：1.12，95%CI：1.03，1.21）。七种 PAHs 的共同暴露与 SUA 和高尿酸血症呈正相关，其中 2&3-OHPh 的权重最高（成分权重：0.83 和 0.78）。CRP 介导了 ΣOHPh 和 2&3-OHPh 与 SUA 关联的 11.47%和 10.44%，以及 ΣOHPh 和 2&3-OHPh 与高尿酸血症关联的 8.60%和 8.62%。总之，美国成年人尿液中多环芳烃代谢物的内源性水平与 SUA 水平升高和高尿酸血症风险增加有关，CRP 在这些关联中起中介作用。
